Tissue-Protective Cytokines

Tissue-Protective Cytokines
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Methods and Protocols
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Artikel-Nr:
9781627033077
Einband:
HC runder Rücken kaschiert
Erscheinungsdatum:
02.03.2013
Seiten:
340
Autor:
Anthony Cerami
Gewicht:
838 g
Format:
260x183x23 mm
Sprache:
Englisch
Beschreibung:

While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.
Thorough and informative, this Methods in Molecular Biology(TM) book presents key models used to characterize the tissue-protective actions of cytokines. Offers lists of materials and reagents, step-by-step laboratory protocols, troubleshooting tips and pitfalls.
Covers many aspects of the tissue-protective actions of erythropoietin (EPO) and other cytokines
1. Erythropoietin and Engineered Innate Repair ActivatorsMichael Brines and Anthony Cerami 2. Epo and Non-hematopoietic Cells: What Do We Know?Omolara O. Ogunshola and Anna Yu. Bogdanova 3. Tissue Protective Cytokines: Structure and EvolutionPietro Ghezzi and Darrell Conklin 4. The Regenerative Activity of Interleukin-6Eithan Galun, and Stefan Rose-John 5. Brain Ischemic Injury in Rodents: The Protective Effect of EPOAnnelise Letourneur, Edwige Petit, Simon Rousse, Omar Touzani , and Myriam Bernaudin 6. Experimental Traumatic Spinal Cord InjuryZubeyde Erbayraktar, Necati Gokmen, Osman Yilmaz, Serhat Erbayraktar, 7. Erythropoietin as a Neuroprotectant for Neonatal Brain Injury: Animal ModelsChristopher M. Traudt and Sandra E. Juul 8. Evaluating Effects of EPO in Rodent Behavioral Assays Related to DepressionCatharine H. Duman and Samuel S. Newton 9. Erythropoietin and Cytoprotective Cytokines in Experimental Traumatic Brain InjurySamson Kumar Gaddam, Jovany Cruz, Claudia Robertson 10. Therapeutic Efficacy of Erythropoietin in Experimental Autoimmune Encephalomyelitis in Mice, a Model of Multiple Sclerosis Ilaria Cervellini, Pietro Ghezzi, Manuela Mengozzi 11. Deciphering the Intracellular Signaling of Erythropoietin in Neuronal CellsMurat Digicaylioglu 12. Assessment of Allodynia Relief by Tissue-protective Molecules in a Rat Model of Nerve Injury-induced Neuropathic PainMaarten Swartjes, Marieke Niesters, Albert Dahan 13. Intra-Epidermal Nerve Fibres Density and Nociception in EPO-treated Type 1 Diabetic Rats with Peripheral Neuropathy Bianchi Roberto, Lombardi Raffaella, Porretta-Serapiglia Carla, Lauria Giuseppe 14. ARA290 in a Rat Model of Inflammatory PainDr Andrew Dilley 15. In Vivo Angiogenic Activity of ErythropoietinDomenico Ribatti 16. Photoreceptor Degeneration in Mice: Adeno-associated Viral (AAV) Vector-Mediated Delivery of ErythropoietinP. Colella and A. Auricchio 17. Myocardial Infarction - Cardioprotection by ErythropoietinMark I. Talan and Roberto Latini 18. Using Plethysmography to Determine Erythropoietin's Impact on Neural Control of VentilationTommy Seaborn, Max Gassmann and Jorge Soliz 19. Cerebral Malaria: Protection by Erythropoietin Anne-Lise Bienvenu and Stephane Picot 18. Using Plethysmography to Determine Erythropoietin's Impact on Neural Control of VentilationTommy Seaborn, Max Gassmann and Jorge Soliz 19. Cerebral Malaria: Protection by Erythropoietin Anne-Lise Bienvenu and Stephane Picot 19. Cerebral Malaria: Protection by Erythropoietin Anne-Lise Bienvenu and Stephane PicotOmolara O. Ogunshola and Anna Yu. Bogdanova 3. Tissue Protective Cytokines: Structure and EvolutionPietro Ghezzi and Darrell Conklin 4. The Regenerative Activity of Interleukin-6Eithan Galun, and Stefan Rose-John 5. Brain Ischemic Injury in Rodents: The Protective Effect of EPOAnnelise Letourneur, Edwige Petit, Simon Rousse, Omar Touzani , and Myriam Bernaudin 6. Experimental Traumatic Spinal Cord InjuryZubeyde Erbayraktar, Necati Gokmen, Osman Yilmaz, Serhat Erbayraktar, 7. Erythropoietin as a Neuroprotectant for Neonatal Brain Injury: Animal ModelsChristopher M. Traudt and Sandra E. Juul 8. Evaluating Effects of EPO in Rodent Behavioral Assays Related to DepressionCatharine H. Duman and Samuel S. Newton 9. Erythropoietin and Cytoprotective Cytokines in Experimental Traumatic Brain InjurySamson Kumar Gaddam, Jovany Cruz, Claudia Robertson 10. Therapeutic Efficacy of Erythropoietin in Experimental Autoimmune Encephalomyelitis in Mice, a Model of Multiple Sclerosis Ilaria Cervellini, Pietro Ghezzi, Manuela Mengozzi 11. Deciphering the Intracellular Signaling of Erythropoietin in Neuronal CellsMurat Digicaylioglu 12. Assessment of Allodynia Relief by Tissue-protective Molecules in a Rat Model of Nerve Injury-induced Neuropathic PainMaarten Swartjes, Marieke Niesters, Albert Dahan 13. Intra-Epidermal Nerve Fibres Density and Nociception in EPO-treated Type 1 Diabetic Rats with Peripheral Neuropathy Bianchi Roberto, Lom

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