The Centrosome

This book surveys classic and modern aspects of centrosome research, expanding on previous topics and offering exciting new aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases.

The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases. Each chapter will be written by experts in their fields who will contribute their unique expertise in specific research fields and include cell and molecular details that are important for the specific subtopics. The book will be comprehensive, concise and will include reviews of key topics in the field. Cutting edge new information will be balanced with background information that will be readily understandable for the newcomer and the experienced centrosome researcher alike.

Centriole Duplication and Inheritance inDrosophila melanogaster.- Sperm Centrioles and their Dual Role in Flagellogenesis and Cell Cycle of the Zygote Structure, Function and Pathology.- Centrosomal Functions and Dysfunctions in Cat Spermatozoa.- Nuclear-Centrosome Relationships During Fertilization, Cell Division, Embryo Development, and in Somatic Cell Nuclear Transfer (SCNT) Embryos.- Human Centrosomal Dynamics During Gametogenesis, Fertilization and Embryogenesis and its Impact on Fertility: Ultrastructure.- Asymmetric Centrosome Behavior in Stem Cell Divisions.- Functional Associations Between the Golgi Apparatus and the Centrosome in Mammalian Cells.- Many Pathways to Destruction: The Centrosome and its Control by and Role in Regulated Proteolysis.- Regulation of the Centrosome Cycle by Protein Degradation.- Molecular Links Between Centrosome Duplication and Other Cell Cycle Associated Events.- Regulation of Centrosomes by Cyclin-Dependent Kinases.- Disruption of Centrosome Duplication Control and Induction of Mitotic Instability by the High-Risk Human Papillomavirus Oncoproteins E6 and E7.- Centrosomes, DNA Damage and Aneuploidy.- Centrosome Regulation and Breast Cancer.- The Role of Centrosomes in Multiple Myeloma.- Centrosomal Amplification and Related Abnormalities Induced by Nucleoside Analogs.- Mechanisms and Consequences of Centrosome Clustering in Cancer Cells.- Re-Evaluation of the Neuronal Centrosome as a Generator of Microtubules for Axons and Dendrites.- Centrosomes and Cell Division in Apicomplexa.- The Centrosome Life Story inXenopus leavis.- Role of the MTOC in T cell Effector Functions.- Thoughts on Progress in the Centrosome Field.