Polyamine Cell Signaling

Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell-Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

Includes supplementary material: sn.pub/extras

Polyamines in Signal Transduction of Cell Proliferation.- Polyamine Structure and Synthetic Analogs.- Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAs.- Polyamine-Dependent Early Cellular Signals and Cell Proliferation.- Cellular Signals Mediating Growth Arrest After Polyamine Depletion.- Role of Polyamines in the Regulation of Chromatin Acetylation.- Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity.- Polyamine Metabolism and the Hypertrophic Heart.- Influence of Polyamines on Breast Cancer Biology.- Polyamines in Regulation of Prostatic Cell Growth.- Polyamines in Kidney Biology.- Polyamines in Pulmonary Vascular Biology.- Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy.- Recent Advances in the Understanding of Mammalian Polyamine Catabolism.- Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells.- The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis.- Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis.- Role of Polyamines in the Control of the Immune Response in the Brain.- Implication of Polyamines in Apoptosis of Immunoresponse Cells.- Polyamines and Cancer.- Polyamine Pools and Cancer Prevention.- Polyamines in Cell Motility and Cell-Cell Interactions.- Polyamines and Cytoskeletal Regulation During Intestinal Epithelial Restitution.- Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells.- Polyamine Block of Kir Channels.- Polyamine Homeostasis and Transport.- Regulation of Ornithine Decarboxylase Expression.- Evidence for a Multistep Model for Eukaryotic Polyamine Transport.- Bacterial and Eukaryotic Transport Systems.- Regulation of S-Adenosylmethionine Decarboxylase.- Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats.