Thyroid Cancer

In this newly updated and revised second edition, Leonard Wartofsky, MD, past president of the American Thyroid Association, and a panel of world-class clinicians critically review all aspects of thyroid cancer from pathogenesis to prognosis, including management and treatment. Organized for rapid access by busy physicians, the book covers both differentiated tumors (papillary carcinoma and follicular carcinoma) and undifferentiated cancers (anaplastic carcinoma, lymphoma, and medullary carcinoma), as well as miscellaneous and unusual cancers of the thyroid. For each tumor type the authors succinctly discuss the key aspects of their clinical presentation, cytology, diagnosis, nuclear isotope scanning evaluation, cellular and biochemical markers, imaging by MRI or CT, monitoring, surgery, pathology, post-operative care, and prognosis. Authoritative and evidenced-based, this second edition of Thyroid Cancer: A Comprehensive Guide to Clinical Management provides in one place everything that physicians treating thyroid cancer patients need to know.

are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.

New Fully Updated Second Edition of the
Management and Treatment of Thyroid Cancer

General Considerations I.- Anatomy and Physiology of the Thyroid Gland.- Epidemiology of Thyroid Cancer.- Molecular Pathogenesis of Thyroid Cancer.- Molecular Aspects of Thyroid Cancer in Children.- Oncogenes in Thyroid Cancer.- Apoptosis in Thyroid Cancer.- Radiation-Induced Thyroid Cancer.- Classification of Thyroid Malignancies.- Staging of Thyroid Cancer.- Thyroid Cancer in Children and Adolescents.- Recombinant Human Thyrotropin.- General Considerations II.- History of the Role of Nuclear Medicine in the Thyroid Gland and its Diseases.- Prophylaxis Against Radiation Exposure from Radioiodine.- Radioiodine Whole Body Imaging.- Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy.- False-Positive Radioiodine Scans in Thyroid Cancer.- The Thyroid Nodule.- The Thyroid Nodule.- Fine-Needle Aspiration.- Thyroid Nodules.- Radionuclide Imaging of Thyroid Nodules.- Ultrasonic Imaging of the Neck in Patients with Thyroid Cancer.- Thyroid Nodules and Cancer Risk.- Well-Differentiated Thyroid Cancer: Papillary Carcinoma.- Papillary Carcinoma.- Surgical Approach to Papillary Carcinoma.- Papillary Carcinoma.- Well-Differentiated Thyroid Cancer.- Prescribed Activity for Radioiodine Ablation.- Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin.- Well-Differentiated Thyroid Cancer.- Follow-Up Strategy in Papillary Thyroid Cancer.- Levothyroxine Therapy and Thyrotropin Suppression.- Thyroglobulin and Thyroglobulin Antibodies.- Diagnosis of Recurrent Thyroid Cancer in Patients with Antithyroglobulin Antibodies.- Surveillance Radioiodine Whole-Body Scans.- Radionuclide Imaging and Treatment of Thyroid Cancer in Children.- Positron Emission Tomography in Well-Differentiated Thyroid Cancer.- Alternative Thyroid Imaging.- Stunning: UntowardEffect of 131I Thyroid Imaging Prior to Radioablation Therapy.- Stunning Is Not a Problem.- Stunning: Does it Exist? A Commentary.- Ultrasonic Imaging and Identification of Metastases in Cervical Lymph Nodes.- Magnetic Resonance Imaging and Computed Tomography of Thyroid Cancer.- Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin.- Determinants of Prognosis in Papillary Thyroid Cancer.- Papillary Cancer.- Special Presentations of Thyroid Cancer in Pregnancy, Renal Failure, Thyrotoxicosis, and Struma Ovarii.- Thyroglossal Duct Carcinoma.- Well-Differentiated Thyroid Cancer.- Radiation and Radioactivity.- Radioiodine Treatment of Distant Metastases.- 131I Treatment of Metastatic Thyroid Carcinoma Following Preparation by Recombinant Human Thyrotropin.- Dosimetry.- Radioiodine Dosimetry with Recombinant Human Thyrotropin.- Use of Lithium as an Adjuvant to Radioiodine in the Treatment of Thyroid Cancer.- Side Effects of 131I for Ablation and Treatment of Well-Differentiated Thyroid Carcinoma.- External Radiation Therapy of Papillary Cancer.- Chemotherapy for Thyroid Cancer.- Chemotherapy of Differentiated Papillary or Follicular Thyroid Carcinoma.- Thyroid Carcinoma.- Adjunctive Local Approaches to Metastatic Thyroid Cancer.- Well-Differentiated Thyroid Cancer.- Follicular Thyroid Carcinoma.- Surgical Management of Follicular Cancer.- Pathology of Follicular Cancer.- Hürthle Cell Carcinoma.- Radionuclide Imaging, Ablation, and Treatment in Follicular Thyroid Carcinoma.- Follow-up Strategy in Follicular Thyroid Cancer.- PET in Follicular Cancer, Including Hürthle Cell Cancer.- Follicular Thyroid Cancer.- External Radiation Therapy of Follicular Carcinoma.- Determinants of Prognosis in Patients With Follicular Thyroid Cancer.-Variants of Thyroid Cancer.- Miscellaneous and Unusual Types of Thyroid Tumors.- Pathology of Miscellaneous and Unusual Cancers of the Thyroid.- Undifferentiated Tumors.- Clinical Aspects of Medullary Thyroid Carcinoma.- Pathology of Medullary Thyroid Cancer.- Medullary Carcinoma of the Thyroid.- Radionuclide Imaging of Medullary Carcinoma.- PET in Medullary Thyroid Cancer.- External Radiation Therapy of Medullary Cancer.- Medullary Carcinoma of the Thyroid.- Undifferentiated Tumors.- Thyroid Lymphoma.- Pathology of Lymphoma of the Thyroid.- FDG-PET Scanning in Lymphoma and Lymphoma of the Thyroid.- Undifferentiated Tumors.- Anaplastic Carcinoma.- Surgical Management of Anaplastic Thyroid Carcinoma.- Pathology of Anaplastic Carcinoma.- PET Scanning in Anaplastic Cancer of the Thyroid.- External Radiation Therapy of Anaplastic Thyroid Cancer.- Chemotherapy for Anaplastic Thyroid Cancer.- Anaplastic Carcinoma.- New Frontiers and Future Directions.- Advances in Radiation Therapy.- New Approaches in Nuclear Medicine for Thyroid Cancer.- Alternative Options and Future Directions for Thyroid Cancer Therapy.- Potential Approaches to Chemotherapy of Thyroid Cancer in the Future.- Resources for Patients with Thyroid Cancer.- Low Iodine Diets.