Dopamine and Glutamate in Psychiatric Disorders

An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. Continous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development.
Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.

Survey of the Neurological Basis and
Treatment Strategies for Neurological Diseases

Dopamine.- Dopamine Receptors.- Dopamine Receptor Alternative Splicing.- Glutamate.- Glutamatergic Pathways.- Glutamate Receptors.- Metabotropic Glutamate Receptors.- Schizophrenia.- Dopamine and Schizophrenia.- Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis.- Role of Glycine in Schizophrenia.- Depression.- Dopamine and Depression.- Glutamate and Depression.- Stress and Aggression.- Dopamine, Glutamate, and Aggression.- Anxiety.- Glutamatergic Systems and Anxiety.- Attention Deficit Hyperactivity Disorder.- Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder.- Addiction.- Dopamine-Glutamate Interactions in Reward-Related Incentive Learning.- Sensitization and Relapse.- Glutamatergic Neurotransmission in Sensitization.- Glutamatergic Mechanisms of Drug Relapse.- Neurodegeneration.- Dopamine and Neurodegeneration.- Glutamate and Neurodegeneration.- Parkinson's Disease.- Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson's Disease.- Dopamine and Glutamate in Parkinson's Disease.- Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson's Disease.- Huntington's Disease.- Dopamine and Glutamate in Huntington's Disease.- Dementias.- Dopaminergic and Glutamatergic Systems in Alzheimer's Disease.