Xenotransplantation

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease. Xenotransplantation might well provide a revolutionary way of augmenting the function of diseased tissues or replacing organs. This possibility has been advanced by newly acquired understanding of the biological and immunological obstacles to conducting transplantation between species. In Xenotransplantation: Basic Research and Clinical Applications, internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft, and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.
Comprehensive and authoritative, Xenotransplantation: Basic Research and Clinical Applications provides basic and clinical investigators, as well as transplant surgeons, with today's most thorough and up-to-date compendium of vital information on all the scientific and technological aspects of xenotransplantation.

Includes supplementary material: sn.pub/extras

1 Molecular and Cellular Hurdles to Xenotransplantation.- 2 Pathological Responses to Xenotransplantation.- 3 Natural Xenoreactive Antibodies.- 4 Specificity of Xenoreactive Natural Antibodies.- 5 Biophysical Properties of Xenoreactive Natural Antibodies.- 6 The Origin of Xenoreactive Natural Antibodies.- 7 Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies.- 8 The Complement Barrier to Xenotransplantation.- 9 Defects and Amplification of Costimulation Across the Species.- 10 Antibody-Dependent Effects on Cellular Immunity.- 11 Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation.- 12 Current Applications of Cellular Xenografts.