The Complete Spleen

Since the publication of The Complete Spleen: Structure, Function, and Clinical Disorders under the title of The Spleen in 1990, there has appeared a wealth of new information that now demands incorporation into the diagnosis and management of patients with splenic disorders. In this 2nd edition, an international panel of distinguished clinical and scientific investigators has thoroughly revised and updated Professor Anthony Bowdler's classic work, emphasizing those functions principally reserved to the spleen, especially the spleen's microvasculature, uniquely adapted to particle filtration, and the consequent mechanisms of its immune responses.
Among the disease aspects critically surveyed in rich detail are the causes of splenic enlargement, the meaning of hypersplenism, hyposplenism and its causes and management, and the unusual cytopenias that accompany the disorders of the spleen, including those caused by maldistribution and dilutional anemias. Diseases given focused attention include the myelo- and lymphoproliferative disorders, hemolytic diseases, and the sickle-cell disorders. These are followed by details of the radiological examination of the spleen, of the present status of surgical intervention, with emphasis on tissue and functional conservation, and of the recently developed laparoscopic methods.
Comprehensive and state-of-the-art, The Complete Spleen: Structure, Function, and Clinical Disorders makes available to all physicians and clinical researchers a coherent account of today's dramatically more detailed knowledge of the spleen and its unique functions as part of the immune system, as well as our optimal current strategies for the management of its pathologies.

Includes supplementary material: sn.pub/extras

I. The Structure and Function of the Spleen.- 1 The Anatomy of the Spleen.- 2 The Microanatomy of the Mammalian Spleen: Mechanisms of Splenic Clearance.- 3 Splenic Microcirculatory Blood Flow and Function with Respect to Red Blood Cells.- 4 The Immune Functions of the Spleen.- 5 The Role of the Spleen in Hemostasis.- II. Characteristics of the Disordered Spleen.- 6 The Pathology of the Spleen.- 7 Splenic Pooling and Survival of Blood Cells.- 8 Dilutional Anemia: Abnormalities of Blood Volume in Disorders of the Spleen.- III. Clinical Aspects of Disorders of the Spleen.- 9 The Clinical Significance of the Spleen.- 10 Hyposplenism.- 11 The Relationship of the Spleen to Infection.- 12 Hemolysis and Thrombocytopenia.- 13 Myeloproliferative Disorders.- 14 The Spleen in Lymphoproliferative Disease.- 15 The Spleen in Sickle Cell Disease.- 16 Imaging of Spleen Disorders.- 17 Surgery of the Spleen.