Handbook of Hematologic Malignancies

Handbook of Hematologic Malignancies provides a unique, practical, and concise guide focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. With an ever-increasing growth of evidence and a significant expansion of available treatment options for patients with hematologic disease, remaining current and up-to-date can be extremely challenging for practicing clinicians. This comprehensive subspecialty handbook is designed and organized for the busy hematologist, hematologic oncologist, hematopathologist, and trainee in mind.

Every chapter is richly illustrated with color figures and flow diagrams, and contains helpful tables on differential diagnosis, prognostic scoring systems and therapeutic options. A concise case-based review for testing pathologic diagnosis and clinical knowledge for each chapter is included for digital download online and in the e-book. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians throughout the country, this handbook is an essential resource for anyone diagnosing, treating, or managing patients with hematologic malignancy.

KEY FEATURES:

• Contains clear prognostic and diagnostic tools (e.g., tables/flow diagrams/pathology images) with emphasis on key differential diagnoses and diagnostic dilemmas
• Easy to use treatment recommendations with bullet point format and key references.
• Discusses the future of patient management based on practice changing clinical trials
• Includes access to digitally downloadable case-based clinical scenarios and questions with high resolution pathology images linked to each individual chapter

Contents

Contributors

Expert Reviewers

Foreword John M. Bennett, MD

Preface

Abbreviations

INTRODUCTION AND OVERVIEW

1. Hematopathology Diagnostic Techniques and Assays

Johnny Nguyen and Ling Zhang

MYELOPROLIFERATIVE NEOPLASMS

2. Polycythemia Vera

Liliana Bustamante and Kenneth Zuckerman

3. Essential Thrombocythemia

Susmitha Apuri and Kenneth Zuckerman

4. Primary Myelofibrosis

Andrew Kuykendall and Kenneth Zuckerman

5. Chronic Myelogenous Leukemia

Chetasi Talati and Javier Pinilla-Ibarz

6. Chronic Neutrophilic Leukemia

Saman Nematollahi, Shweta Jain, and Utkarsh Acharya

7. Systemic Mastocytosis

Andrew Kuykendall and Kenneth Zuckerman

8. PDGFRA/PDGFRB/FGFR1 Myeloid Neoplasms

Joseph Clara and Eric Padron

MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES

9. Myelodysplastic Syndromes

Joanna Grabska, David A. Sallman, and Rami Komrokji

10. Aplastic Anemia

Michael Shafique and Rami Komrokji

11. Paroxysmal Nocturnal Hemoglobinuria

Hilda Ding and Michael Jaglal

MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS

12. Myelodysplastic/Myeloproliferative Overlap Syndromes

Jennifer Eatrides and Eric Padron

13. Chronic Myelomonocytic Leukemia

Alexandra Gomez and Justin M. Watts

ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES

14. Acute Myeloid Leukemia

Varun Dhulipala and Kendra Sweet

15. Secondary AML and AML With Myelodysplasia-Related Changes

Seongseok Yun and Jeffrey Lancet

16. Acute Promyelocytic Leukemia

Leidy L. Isenalumhe and Jeffrey Lancet

17. Blastic Plasmacytoid Dendritic Cell Neoplasm

Justin Taylor, Ateefa Chaudhury, and Andrew A. Lane

ACUTE LYMPHOID LEUKEMIA

18. B-Lymphoblastic Leukemia

Aneesha Hossain and Khaled el-Shami

19. BCR-ABL1+ B-Lymphoblastic Leukemia

Aneesha Hossain and Khaled el-Shami

20. T-Lymphoblastic Lymphoma/Leukemia

Keri Maher and Ravitharan Krishnadasan

ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE

21. Acute Leukemia of Ambiguous Lineage

Keri Maher and Ravitharan Krishnadasan

MATURE T- AND NK-CELL LEUKEMIA

22. T-Cell Prolymphocytic Leukemia

Abhijeet Kumar, Srinath Sundararajan, and Ravitharan Krishnadasan

23. T-Cell Large Granular Lymphocytic Leukemia

Magali Van den Bergh and Lubomir Sokol

24. Aggressive Natural Killer Cell Leukemia

Mintallah Haider and Lubomir Sokol

PLASMA CELL DISORDERS

25. Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas

Srinath Sundararajan, Abhijeet Kumar, Amit Agarwal, and Neha Korde

26. Multiple Myeloma

Patrick Griffin and Rachid Baz

27. Waldenström’s Macroglobulinemia

Joanna Grabska and Rachid Baz

28. Immunoglobulin Light Chain Amyloidosis

Taxiarchis Kourelis and Morie A. Gertz

HODGKIN LYMPHOMA

29. Hodgkin Lymphoma

Anju Nair and Micah Burch

NON-HODGKIN LYMPHOMA

30. Non-Hodgkin Lymphoma Classification and Diagnostic Evaluation

Johnny Nguyen and Ling Zhang

MATURE B-CELL LYMPHOMA

VERY AGGRESSIVE

31. Burkitt Lymphoma

Anju Nair and Micah Burch

AGGRESSIVE

32. Diffuse Large B-Cell Lymphoma

Jose Sandoval-Sus and Julio Chavez

33. Double Hit Lymphoma

Nikhil Mukhi and Julio Chavez

34. Mantle Cell Lymphoma

Samantha Shams and Bijal Shah

35. Primary Mediastinal Large B-Cell Lymphoma

Andreas Saltos and Julio Chavez

36. Primary Central Nervous System Lymphoma

Liliana Bustamante and Peter Forsyth

37. HIV-Related Lymphomas

Danny Nguyen, Nishan Tchekmedyian, and Jeremy Abramson

INDOLENT

38. Follicular Lymphoma

Asha Balakrishnan and Celeste Bello

39. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Ateefa Chaudhury and Javier Pinilla-Ibarz

40. Hairy Cell Leukemia

Justin Taylor and Omar Abdel-Wahab

41. Marginal Zone Lymphoma

Nishan Tchekmedyian, Danny Nguyen, and Celeste Bello

42. Mucosa-Associated Lymphoid Tissue Lymphoma

Ridhi Gupta, Matthew Mastrodomenico, Nishan Tchekmedyian, and Saurabh Chhabra

MATURE T/NK-CELL LYMPHOMA

43. Adult T-Cell Leukemia/Lymphoma

Nikhil Mukhi and Lubomir Sokol

44. Anaplastic Large Cell Lymphoma, ALK Positive

Thomas Enzler and Changchun Deng

45. Extranodal Natural Killer/T-Cell Lymphoma

Joseph Clara and Lubomir Sokol

46. Mycosis Fungoides

Achuta Kumar Guddati and Lubomir Sokol

47. Hepatosplenic T-Cell Lymphoma

Narendranath Epperla, Apoorva Jayarangaiah, and Timothy S. Fenske

HISTIOCYTIC/DENDRITIC CELL NEOPLASMS

48. Histiocytic Sarcoma and Langerhans Cell Histiocytosis

Narendranath Epperla and Ehab Atallah

49. Hemophagocytic Lymphohistiocytosis

Hilda Ding and Lubomir Sokol

BONE MARROW TRANSPLANTATION

50. Autologous Bone Marrow Transplantation

Hemant S. Murthy and Mohamed A. Kharfan-Dabaja

51. Allogeneic Bone Marrow Transplantation

Hemant S. Murthy, Taiga Nishihori, and Mohamed A. Kharfan-Dabaja

EMERGENCIES IN HEMATOLOGY

52. Tumor Lysis Syndrome

Mintallah Haider, Ateefa Chaudhury, and Michael Jaglal

53. Thrombotic Microangiopathy

Ruchika Goel, Aaron Tobian, and Ljiljana V. Vasovic

54. Therapeutic Apheresis Indications

Amanda E. Lo, Ruchika Goel, and Ljiljana V. Vasovic

Appendix: Pathology Supplement

Index