The American Psychiatric Association Publishing Textbook of Psychopharmacology

Unrivaled in its rigor and relevance, The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable resource for all clinicians who prescribe psychotropic medications.

More than 160 authors—including more than 75 new contributors—lent their expertise to this sixth edition of The American Psychiatric Association Publishing Textbook of Psychopharmacology. Featuring 12 all-new chapters and fully aligned with the revised DSM-5-TR classification, this two-volume text offers an unrivaled, in-depth look at the rapidly evolving field of neuropsychopharmacology.

The opening chapters provide a whirlwind tour of the multiple disciplines that undergird the chapters to come, with topics extending from the principles of molecular biology and genomics to the rudiments of neuroimaging and personalized medicine in psychiatry. The main body of the Textbook features an examination of the medication classes that form the basis of psychopharmacological treatment. For each drug within a class, data are reviewed on history and discovery, preclinical and clinical pharmacology, pharmacokinetic parameters, mechanism of action, indications and efficacy, side effects and toxicology, and drug-drug interactions. The Textbook's second volume focuses on psychopharmacological approaches to treatment of patients with major psychiatric disorders (e.g., mood and anxiety disorders, schizophrenia, substance use disorders) as well as patients in specific populations (e.g., adults with ADHD, pediatric patients). For each specific condition, patient population, or setting, chapters provide guidance on topics such as medication selection, combination and maintenance dosing regimens, side-effect monitoring and management, and optimization of treatment response. Closing this volume is an Appendix of Psychiatric Medications with key information on each of the agents covered in the Textbook, presented in a convenient tabular format.

Noteworthy additions to this textbook include chapters addressing the following topics:

• The potential roles of personalized medicine in psychiatry and of artificial intelligence and machine learning in psychopharmacology• New medications with novel pharmacological mechanisms, including the neurosteroid antidepressant brexanolone and the atypical antipsychotic pimavanserin• Use of investigational agents, such as psychedelics, in psychiatric treatment• Treatment of alcohol use disorder, PTSD, OCD, and autism spectrum disorder• Treatment of ADHD in adults• Treatment of women in all life phases, including during pregnancy and the postpartum period• Treatment of individuals with intellectual developmental disorder

With a level of detail not found in any other source, this new edition of The American Psychiatric Association Publishing Textbook of Psychopharmacology illuminates the path to effective evidence-based practice of psychopharmacology for novice and seasoned clinicians alike.

Contents ContributorsIntroduction PART I Principles of Pharmacology Chapter 1. Basic Principles of Molecular Biology and GenomicsChapter 2. Neurotransmitters, Receptors, and TransportersChapter 3. Genetics and Epigenetics Chapter 4. Psychoneuroendocrinology Chapter 5. Brain–Immune System Interactions Chapter 6. Pharmacokinetics, Pharmacodynamics, and PharmacogenomicsChapter 7. Neuroimaging and PsychiatryChapter 8. Personalized Medicine in Psychiatry Chapter 9. Machine Learning in Psychopharmacology Chapter 10. Monoamine Oxidase Inhibitors.Chapter 11. Tricyclic and Tetracyclic DrugsChapter 12. Fluoxetine and Fluvoxamine Chapter 13. Sertraline and ParoxetineChapter 14. Citalopram and EscitalopramChapter 15. Trazodone and NefazodoneChapter 16. Vortioxetine Chapter 17. MirtazapineChapter 18. BupropionChapter 19. Venlafaxine and DesvenlafaxineChapter 20. Duloxetine, Milnacipran, and LevomilnacipranChapter 21. Ketamine and EsketamineChapter 22. BenzodiazepinesChapter 23. Buspirone Chapter 24. Brexanolone and Other NeurosteroidsChapter 25. Classic Antipsychotic MedicationsChapter 26. Clozapine Chapter 27. OlanzapineChapter 28. Quetiapine Chapter 29. Risperidone and Paliperidone Chapter 30. Aripiprazole and BrexpiprazoleChapter 31. Ziprasidone and AsenapineChapter 32. IloperidoneChapter 33. LurasidoneChapter 34. CariprazineChapter 35. Pimavanserin Chapter 36. Management of Psychiatric Medication–Induced Movement DisordersChapter 37. LithiumChapter 38. Valproate Chapter 39. Carbamazepine, Oxcarbazepine, and Licarbazepine Chapter 40. Gabapentin and PregabalinChapter 41. LamotrigineChapter 42. TopiramateChapter 43. Agents for Cognitive DisordersChapter 44. Sedative-HypnoticsChapter 45. Psychostimulants and Wakefulness-Promoting AgentsChapter 46. Electroconvulsive Therapy and Other Neuromodulation Therapies Chapter 47. Psychedelic Drugs as Treatments in PsychiatryPART III Psychopharmacological Treatment Chapter 48. Treatment of Depression Chapter 49. Treatment of Bipolar DisorderChapter 50. Treatment of Anxiety and Related Disorders Chapter 51. Treatment of Posttraumatic Stress DisorderChapter 52. Treatment of Obsessive-Compulsive Disorder Chapter 53. Treatment of SchizophreniaChapter 54. Treatment of Substance Use DisordersChapter 55. Treatment of Alcohol Use Disorder Chapter 56. Treatment of Personality DisordersChapter 57. Treatment of Eating DisordersChapter 58. Treatment of Insomnia Chapter 59. Treatment of Chronic Pain Chapter 60. Treatment of Child and Adolescent DisordersChapter 61. Treatment During Late LifeChapter 62. Treatment of Women Excluding Pregnancy and PostpartumChapter 63. Treatment of Women During Pregnancy and LactationChapter 64. Treatment of Attention-Deficit/Hyperactivity Disorder in AdultsChapter 65. Treatment of Individuals With Intellectual Developmental DisorderChapter 66. Treatment of Autism Spectrum Disorder Chapter 67. Treatment of Psychiatric Emergencies.AppendixPsychiatric MedicationsIndex