Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease

It is a pleasure to introduce this new book, Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Disease, edited by two of my friends and respected colleagues, Franco Rongioletti and Bruce R. Smoller. In fact, I was very ent- siastic when I learned that they were preparing this work. Although endocrine, metabolic, w, and deposition diseases are regularly included in general textbooks of dermatology and d- matopathology, one gains the general impression that these topics receive little emphasis and are mainly included for completeness. The prospect of having all of this information in one volume, lovingly described and detailed by experts in the feld, should be of great interest not only to dermatologists, pathologists, and dermatopathologists but also to internists and en- crinologists, who may well gain a different perspective on these disorders. As a derma- pathologist, I am also pleased that this project has been organized and undertaken by two distinguished authorities in cutaneous pathology. This assures a close integration of histo- thology and other laboratory techniques with the clinical aspects of these disorders, which will make it possible - perhaps for the frst time - to view these conditions in a truly comprehensive way. So I invite you, the reader, to open this volume and dig in; be prepared for an eye-catching, intellectually stimulating, and ultimately rewarding experience! Charlottesville, VA James W. Patterson v w Foreword II Dermatopathology is a bridge between Dermatology and Pathology.

With a unique combination of clinical photographs and histological photomicrographs, this reference work is a single-volume source that reviews the clinical and pathologic features of metabolic and endocrine disorders displaying cutaneous manifestations.

Unique presentation of clinical photographs and accompanying histologic photomicrographs

Part I. CUTANEOUS ENDOCRINE DISEASE1. ADRENAL DISEASEKennet Calder/Bruce Smoller1.1.Cushing's syndrome1.2.Addison's disease1.3.Pheocromocytoma2. PANCREAS DISEASE AND DIABETES MELLITUSFranco Rongioletti2.1. Non infectious skin manifestations2.1.1 Necrobiosis lipoidica2.1.2 Diabetic dermopathy2.1.3 Granuloma annulare2.1.4 Diabetic thick skin2.1.5 Bullosis diabeticorum2.1.6 Eruptive xanthomas2.1.7 Acquired perforating dermatosis2.1.8 Acanthosis nigricans2.1.9 Miscellanea2.2 Cutaneous infections2.2.1 Bacterial Infections2.2.2 Candida Infections2.2.3 Dermatophyte Infections2.2.4 Rare infections2.3 Complications due to diabetic neuropathy and vasculopathy2.4 Complications due to diabetes treatment3. THYROID DISEASEAlfredo Rebora/Franco Rongioletti3.1.Hyperthyroidism3.2.Hypothyroidism4. PITUITARY GLAND DISEASEMartina Montinari/Franco Rongioletti4.1. Acromegaly4.2. Hyperprolactinemia4.3 Cushing's disease4.4 Panhypopituitarism5. PARATHYROID DISEASEYann Charli-Joseph/Marcela Saeb-Lima5.1.Hyperparathyroidism5.1.1 Familial (hereditary) forms of primary hyperparathyroidism5.1.2 Hyperparathyroidism related to renal failure5.1.3 Other cutaneous manifestations5.2. HypoparathyroidismPart II.CUTANEOUS METABOLIC DISEASE6. DYSLIPIDEMIA (HYPERLIPIDEMIA)Terry Katona/Bruce Smoller6.1 Specific xanthomas6.1.1 Planar xanthomas6.1.2 Eruptive xanthomas6.1.3 Tuberous xanthomas6.1.4 Tendinous xanthomas6.1.5 Cholesterotic fibrous histiocytoma7. GOUTUma Sundram8.LIPOMATOSISUma Sundram8.1 Diffuse lipomatosis8.2 Familial multiple lipomatosis8.3 Multiple symmetric lipomatosis8.4 Adiposis dolorosa (Dercum's disease)8.5 Syndromes that can demonstrate multiple lipomas8.5.1 Proteus syndrome8.5.2 Bannayan-Zonana syndrome9.OBESITYJessica Linder/Amena Usmani/Maria Miteva/Camillo Ricordi/Paolo Romanelli9.1 Achrocordons9.2 Adiposis dolorosa9.3 Hidradenitis suppurativa9.4 Lymphedema9.5Acanthosis nigricans9.6 Strie distensae9.7 Hyperandrogenism9.8 Plantar hyperkeratosis9.9 Other skin manifestations10.PORPHYRIASJaqueline Junkins-Hopkins10.1 Congenital erythropoietic porphyria (CEP)10.2 Porphyria cutanea tarda10.3 Erythropoietic protoporphyria10.4 Hepatoerythropoietic porphyria10.5 Pseudoporphyria11.HEMOCHROMATOSISAurora Parodi/Franco Rongioletti12.THE METABOLIC SYNDROME IN PSORIASISPaolo Gisondi/GiampieroGirolomoniIII. CUTANEOUS NUTRITIONAL DISEASE13.ACQUIRED NUTRITIONAL DEFICIENCIESMartina Montinari/Aurora Parodi/Franco Rongioletti13.1 Scurvy13.2 Acquired acrodermatitis enteropatica (dermatitis associated with zinc deficiency)13.3 Pellagra13.4 Iron deficiency13.5 Other nutritional deficiencies14.ANOREXIA NERVOSAJameel Ahmad Brown14.1 Xerosis14.2 Lanugo-like body hairs14.3 Alopecia14.4 Hypercarotenemia/Carotenoderma14.5 Acne14.6 Acrocyanosis14.7 Pruritus14.8 Purpura14.9 Nail Changes14.10 Angular Cheilitis14.11 Russell's Sign14.12 Finger Clubbing, fixed drug eruption, and photosensitivity dermatitis14.13 Miscellanea15.ALCOHOL ABUSETorello Lotti/ Angelo Massimiliano D'Erme15.1 Skin diseases significantly associated with alcoholism15.2 Nutritional and metabolic diseases with skin symptoms induced by alcoholism15.3 Skin diseases exacerbated by alcohol16.GLUCAGONOMA SYNDROME AND NECROLYTIC MIGRATORY ERYTHEMAFranco RongiolettiIV. CUTANEOUS DEPOSITION DISEASE17. AMYLOIDOSESFranco Rongioletti17.1 Acquired systemic amylodoses with cutaneous involvement17.1.1 Primary and myeloma-associated amyloidosis (AL amyloidosis)17.1.2 Secondary systemic AA amyloidosis17.1.3 ? 2-Microglobulin hemodialysis-associated amyloidosis17.2. Hereditary/familial systemic amyloidoses with cutaneous involvement17.3. Localized cutaneous amyloidoses17.3.1Primary localized cutaneous amyloidoses17.3.2. Secondary localized cutaneous amyloidosis18.MUCINOSESFranco Rongioletti18.1