Alzheimer’s Disease

In the second edition of this well-known, comprehensive title on Alzheimer s Disease, prominent Alzheimer's investigators from throughout the world provide an updated and expanded overview of therapeutics for this devastating disease. Divided into five parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment covers epidemiology, including the global economic burden and risk factors for developing AD. Section three, greatly expanded from the first edition, explores the full range of issues involved in clinical assessment, while sections four and five cover the transitional stage and treatment options, respectively.

The second edition of this well-known, comprehensive text provides an updated and expanded overview of therapeutics for this devastating disease. It covers epidemiology, treatment options, and the full range of issues regarding clinical assessment.

Preface
Contributors
Part I Scientific Background of Alzheimer s Disease
1 Genetics of Alzheimer s Disease and Related Disorders
John Hardy
2 Neuropathology of Alzheimer s Disease
Christian Schultz, Kelly Del Tredici, and Heiko Braak
3 Oxidative Stress in the Development of Alzheimer s Disease
and Other Dementias
Domenico Praticò
4 Metabolism and Alzheimer s Disease
John P. Blass
Part II Epidemiology
5 Alzheimer s Disease: Epidemiological and Statistical Data
Brigitte Zoeller Richter and Ralph W. Richter
6 The Economic Burden of Alzheimer s Disease and Dementia
Anders Wimo and Bengt Winblad
7 Potential and Established Risk Factors for Alzheimer s Disease
Brigitte Zoeller Richter
Part III Clinical Assessment
8 Medical Diagnosis and Workup of Alzheimer s Disease
Ralph W. Richter
9 Neuroimaging Techniques: CT, MRI, SPECT, PET
Norman L. Foster
10 Computer-assisted cognitive assessment & enhancement (K. Wesnes, MD, UK)
11 Normal Pressure Hydrocephalus (P. Reyes, Prof., San Antonio, TX & R.W. Richter, Prof. Tulsa, OK)
12 Interface between depression and cognitive impairment (D.P. Devanand, Prof., Columbia U, NY)
13 Insulin, Diabetes, Alzheimer Disease the interplay (S. Kraft, Prof. U Seattle/WA)
AD and the eye (retinal amyloid plaques)
14 Inflammatory and immunological aspects of dementia (D. Morgan, Prof., U South Florida)
15 Non pharmacological interventions in dementia (A. Burns, Prof. U Manchester/UK)
16 Biological Markers in Alzheimer s Disease
Ramon Diaz-Arrastia and Fred Baskin
17 The Neuropsychology of Alzheimer s Disease
Kirsten I. Taylor and Andreas U. Monsch
18 Vascular Cognitive Impairment in Clinical Practice
Kenneth Rockwood and Timo Erkinjuntti
19 Lewy Body Disease
Robert Barber, Jane Newby, and Ian G. McKeith
20 Frontotemporal Lobe Dementia
Malgorzata Franczak, Diana Kerwin, and Piero Antuono
Part IV The Transitional Stage
21 Mild Forgetfulness: Distinguishing Early AD from Normal Aging
Scott A. Small
16 Mild Cognitive Impairment: What the Physician Should Know
Brigitte Zoeller Richter
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22 Diagnosis of Predementia AD in a Clinical Setting
Pieter Jelle Visser
23Loss of Olfactory Function in Patients With Alzheimer s Disease
Claire Murphy and Paul E. Gilbert
Part V Treatment Options
24 Treatment of Alzheimer s Disease: Basic Considerations
Brigitte Zoeller Richter and Ralph W. Richter
25 Donepezil in Treatment of AD
Ging-Yuek Robin Hsiung and Howard Feldman
26 Rivastigmine for Treatment of AD
Martin R. Farlow
27 Galantamine in Treatment of AD
M. Saleem Ismail and Pierre N. Tariot
28 Memantine in Treatment of AD
Hans Jörg Möbius
29 Alternative Treatment Options
Brigitte Zoeller Richter
Part VI Late-Stage Therapy
30 Pain and Palliative Care in Late-Stage Dementia Patients
Sophie Pautex, Dina Zekry, Gilbert Zulian, Gabriel Gold,
and Jean-Pierre Michel
31 Cardiological Issues in Late-Stage Alzheimer s Disease:
A Clinician s Approach
José R. Medina
Part VII Prevention Strategies
32 Neuroprotection and Neurodegenerative Disease
Frank John Emery Vajda
33 Neurotrophic Factors for Prevention of Alzheimer s Disease
Mark H. Tuszynski
34 Statins in Prevention and Treatment of Alzheimer s Disease
David A. Drachman
35 Potential Role of Androgens and Androgen Receptors
in Alzheimer s Disease
Jacob Raber
36 Role of Nutrition in Prevention or Delay of Alzheimer s Disease
Hannes B. Staehelin
37 Impact of Physical Activity on Prevention of Alzheimer s Disease
Danielle Laurin, René Verreault, and Joan Lindsay
Part VIII Future Developments
38 Stem Cell Therapy for Alzheimer s Disease
Kiminobu Sugaya
39 Secretases as