Principles of Molecular Cardiology

In recent years our understanding of the genetic links to cardiovascular disease has increased dramatically, helping to redefine the etiology and diagnostic criteria for numerous conditions, and allowing the development of novel, individualized treatments. In Principles of Molecular Cardiology leading specialists explore all the latest developments in molecular cardiologic research and therapy. The authors explain in a concise yet readable style the complex process of the heart's development, the molecular bases of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases, and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.
Authoritative and up-to-date, Principles of Molecular Cardiology offers cardiovascular scientists and fellows not only a quick yet insightful tour from bench to bedside of the molecular mechanisms underlying cardiovascular disease, but also an introduction to the just-now emerging therapies based on our enriched understanding of the heart's molecular biology and genetics.

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Overview.- Cardiovascular Genetics.- Molecular Biology Applications in Cardiovascular Medicine.- Genomics and Its Application to Cardiovascular Disease.- Gene Therapy and Cardiovascular Diseases.- Stem Cells and Progenitor Cells in Cardiovascular Disease.- Myocardial Disease.- Development of the Vertebrate Heart.- Inherited Myocardial Diseases.- Receptor-Signaling Pathways in Heart Failure.- Recent Insights into the Molecular Pathophysiology of Viral Myocarditis.- Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease.- Coronary Artery Disease.- Coronary Artery Development.- Atherosclerosis.- Antiplatelet Drugs.- Myocardial Infarction.- Transplant Arteriopathy.- Thrombolysis.- Coronary Restenosis.- Arrhythmias.- Induction and Patterning of the Purkinje Fiber Network.- Mechanisms of Sudden Cardiac Death.- Gene Therapy for Cardiac Arrhythmias.- Genetics and Arrhythmias.- Vascular Diseases.- Therapeutic Angiogenesis for Ischemic Vascular Disease.- Nitric Oxide in Cardiovascular Biology and Pathophysiology.- Vasculitis.- Primary Pulmonary Hypertension.- The Molecular Basis of Cerebrovascular Malformations.- Thrombotic Vascular Disease.- Risk Factors.- Risk Factors.- Vascular Aging.- Oxidative Stress.- Diabetes Mellitus.- Vascular Inflammation as a Cardiovascular Risk Factor.