The Chromosomal Imbalance Theory of Cancer

Rasnick, David

Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades.

Introducing CancerBoveri's Theory of Cancer was Ahead of its Time: Aneuploidy theory "Got Lost".Genesis of "The Enemy Within"? Clonal cancer. Tumorigenic retroviruses. Dominate oncogenes. Tumor suppressor genes. Driver genes.Gene Mutation Theory of Cancer: "Carcinogens are mutagens". Retroviral oncogenes. Are "cellular oncogenes" like retroviral oncogenes? Updated gene mutation theory is popular but unconfirmed.The Chromosomal Imbalance Theory of Cancer: Heuristic explanation of how chromosomal imbalance (and not gene mutation) generates cancer phenotypes. Aneuploidy causes chromosomal instability-the hallmark of cancer. Cancer is a progressive somatic aneuploidy syndrome. Quantitative analysis of how aneuploidy generates new cellular phenotypes.Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes: Carcinogenesis is dependent on aneuploidy and not mutation. Autocatalyzed progression of aneuploidy is carcinogenesis. Aneuploidy causes the Warburg effect by increasing ATP demand. Balanced mitotic forces and species-specific sequential chromatid separation may govern the rate of transformation. Cancer vaccine is very unlikely. "Cancers are a genuine type of species"New Perspectives for Cancer Prevention, Diagnosis and Therapy: International regulation of aneuploidy-inducing agents. Cancer detection. Cancer therapy.Conclusion