Molecular Microbiology

Presenting the latest molecular diagnostic techniques in one comprehensive volume
 
The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field.
 
Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors.
 
Molecular Microbiology: Diagnostic Principles and Practice
* Presents the latest basic scientific theory underlying molecular diagnostics
* Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing
* Illustrates and summarizes key concepts and techniques with detailed figures and tables
* Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance
* Advises on the latest quality control and quality assurance measures
* Explores the increasing opportunities and capabilities of information technology
 
Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians.

Contributors
 
Preface
 
Section I: Novel and Emerging Technologies
 
1 Nucleic Acid Amplification Methods Overview
 
2 Application of Identification of Bacteria by DNA Target Sequencing in a Clinical Microbiology Laboratory
 
3 Microbial Whole-Genome Sequencing: Applications in Clinical Microbiology and Public Health
 
4 Digital PCR and Its Potential Application to Microbiology
 
5 Massively Parallel DNA Sequencing and Microbiology
 
6 Next-Generation Sequencing
 
7 Pathogen Discovery
 
8 Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Microbial Identification in Clinical Microbiology
 
9 Multiplex Technologies
 
Section II: Metagenomics: Implications for Diagnostics
 
10 The Skin Microbiome: Insights into Potential Impact on Diagnostic Practice
 
11 The Gastrointestinal Microbiome
 
12 The Vaginal Microbiome
 
13 Microbial Communities of the Male Urethra
 
14 The Human Virome in Health and Disease
 
Section III: Health Care-Associated Infections
 
15 Molecular Detection of Staphylococcus aureus Colonization and Infection
 
16 Molecular Diagnostics for Clostridium difficile
 
17 Overview of Molecular Diagnostics in Multiple-Drug-Resistant Organism Prevention: Focus on Multiple-Drug-Resistant Gram-Negative Bacterial Organisms
 
18 Detection of Vancomycin-Resistant Enterococci
 
Section IV: Molecular Diagnostics and Public Health
 
19 The Impact of Molecular Diagnostics on Surveillance of Foodborne Infections
 
20 Role of Molecular Methods in Improving Public Health Surveillance of Infections Caused by Antimicrobial-Resistant Bacteria in Health Care and Community Settings
 
21 Molecular Diagnostics: Huge Impact on the Improvement of Public Health in China
 
22 Surveillance and Epidemiology of Norovirus Infections
 
23 Molecular Diagnostic Assays for the Detection and Control of Zoonotic Diseases
 
Section V: Syndromic Diagnostics
 
24 Molecular Approaches to the Diagnosis of Meningitis and Encephalitis
 
25 Using Nucleic Acid Amplification Techniques in a Syndrome-Oriented Approach: Detection of Respiratory Agents
 
26 Molecular and Mass Spectrometry Detection and Identification of Causative Agents of Bloodstream Infections
 
27 Molecular Diagnosis of Gastrointestinal Infections
 
28 Diagnostic Approaches to Genitourinary Tract Infections
 
29 Syndromic Diagnostic Approaches to Bone and Joint Infections
 
Section VI: Virology
 
30 Molecular Detection and Characterization of Human Immunodeficiency Virus Type 1
 
31 Molecular Detection and Characterization of Hepatitis C Virus
 
32 Molecular Detection and Characterization of Hepatitis B Virus
 
33 Molecular Detection of Human Papillomaviruses
 
34 Molecular Diagnostics for Viral Infections in Transplant Recipients
 
Section VII: Fungi and Protozoa
 
35 Molecular Detection and Identification of Fungal Pathogens
 
36 Molecular Approaches for Diagnosis of Chagas' Disease and Genotyping of Trypanosoma cruzi
 
37 Molecular Approaches for Diagnosis of Malaria and the Characterization of Genetic Markers for Drug Resistance
 
38 Molecular Detection of Gastrointestinal Parasites
 
Section VIII: Point-of-Care/Near-Care Diagnostics
 
39 Molecular Diagnostics and the Changing Face of Point-of-Care
 
40 Point-of-Care Technologies for the Diagnosis of Active Tuberculosis
 
41 Molecular Diagnostics for Use in HIV/AIDS Care and Treatment in Resource-Limited Settings
 
42 Rapid Point-of-Care Diagnosis of Malaria a

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