Thyroid Cancer
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Thyroid Cancer

A Comprehensive Guide to Clinical Management, Originaltitel:Thyroid Cancer
 eBook
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ISBN-13:
9781493933143
Einband:
eBook
Seiten:
1049
Autor:
Leonard Wartofsky
eBook Typ:
PDF
eBook Format:
eBook
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:

Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field’s leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer. 



PART I. General Considerations  I :  THYROID CANCER


1 Anatomy and Physiology of the thyroid gland: Clinical Correlates to Thyroid Cancer


2 Epidemiology of Thyroid Cancer


3 Molecular Pathogenesis of Thyroid Cancer & Oncogenes in Thyroid Cancer


4 Molecular Aspects of Thyroid Cancer in Children


5 The Role of Genetics in the Development of Familial Non-Medullary Thyroid Cancer


6 Apoptosis in Thyroid Cancer


7 Radiation-Induced Thyroid Cancer


8 Classification of Thyroid Malignancies


9 Staging of Thyroid Cancer


10 Recombinant human Thyrotropin (Thyrogen®)


PART II. GENERAL CONSIDERATIONS II:  NUCLEAR MEDICINE


11 Radioiodine Whole Body Imaging


12 Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy


13 False-Positive Radioiodine-131 scans in Thyroid Cancer


14 The Utility of SPECT-CT in Differentiated Thyroid Cancer


15 Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for staging and risk stratification.


16 Stunning by 131I scanning: Untoward Effect of 131I Thyroid Imaging Prior to Radioablation Therapy


17 Stunning is Not a Problem


18 Stunning: Does it Exist? A Commentary


19 To Perform or Not to Perform Radioiodine Scans Prior to 131I Remnant Ablation?


PART III. THE THYROID NODULE


20 The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management


21 Fine-Needle Aspiration



22 Diagnostic and Prognostic Molecular Markers in Thyroid Cancer 




23 Ultrasonic Imaging of the Thyroid Gland


24 Radionuclide Imaging of Thyroid Nodules


25 18F Fluoro-deoxyglucose PET and Thyroid Nodules


26 Thyroid Nodules and Cancer Risk: Surgical Management


27 Thyroid Nodules in Children and Cancer Risk


28 Management of the Thyroid Nodule: A Comparison Of Published International Guidelines


PART IV. WELL-DIFFERENTIATED THYROID CANCER A: PAPILLARY CARCINOMA: PRESENTATION


29 Papillary Carcinoma: Clinical Aspects


30 Papillary Microcarcinoma


31 Surgical Approach to Papillary Thyroid Cancer


32 Papillary Carcinoma: Cytology and Pathology                            


B.  INITIAL MANAGEMENT


33 Remnant Ablation, Adjuvant Treatment and Treatment of Locoregional Metastases with 131I


34 Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin


C.  SURVEILLANCE


35 Follow-up Strategy in Papillary Thyroid Cancer


36 Thyroid Hormone Therapy and Thyrotropin Suppression


37 Thyroglobulin for Differentiated Thyroid Cancer: Measurement and Interferences


38 Thyroglobulin Antibodies and Their Measurement


39 Diagnosis of Recurrent Thyroid Cancer in Patients with Anti-Thyroglobulin Antibodies



40 Ultrasound of the neck lymph nodes


41 Surveillance Radioiodine Whole Body Scans


42 Radionuclide Imaging and Treatment of Children with Thyroid Cancer


43 Positron Emission Tomography-/Computed Tomography (PET-CT and PET) in Well-Differentiated Thyroid Cancer



44 Alternative Thyroid Imaging


45 MR and CT Imaging of Thyroid Cancer


46 Thyroglobulin in Lymph Node Aspirate


47 Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin


48 Prognosis in Papillary Thyroid Cancer


49 Surgical Management of Lymph Node Metastases


50 Utility of Second Surgery for Lymph Node Metastases


51 Papillary Cancer Special Aspects in Children


52 Special Presentations of Thyroid Cancer in Thyrotoxicosis, Renal Failure, and Struma Ovarii


53 Thyroglossal Duct Carcinoma


54 Thyroid Cancer in Pregnancy


D. TREATMENT


55 Radiation and Radioactivity


56 131I Treatment of Distant Metastases


57 Treatment of Metastatic Thyroid Cancer with Radioiodine following preparation by Recombinant Human Thyrotopin


58 Dosimetrically-Determined Prescribed Activity of 131I for the Treatment of Metastatic Differentiated Thyroid Carcinoma


59 Simplified Methods of Dosimetry


60 Radioiodine Dosimetry with Recombinant human Thyrotropin   



61 The Use of Lithium as an Adjuvant to Radioiodine In the Treatment of Thyroid Cancer


62 Side Effects of 131I for Therapy of Differentiated Thyroid Carcinoma


63 Radiation Therapy in Papillary Carcinoma



64 Chemotherapy of Thyroid Cancer: General Principles



65 Bone Metastases from Differentiated Thyroid Carcinoma




66 A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer


67 Adjunctive Local Approaches to Thyroid Nodules and Metastatic Thyroid Cancer


68 Radioiodine-Refractory Thyroid Cancer: Restoring Response to Radioiodine Therapy


69 Alternative and Complementary Treatment of Thyroid Disorders                       


PART V. WELL-DIFFERENTIATED THYROID CANCER  FOLLICULAR CARCINOMA


70 Follicular Thyroid Carcinoma


71 Surgical Management of Follicular Cancer


72 Pathology of Follicular Cancer


73 Hürthle Cell Carcinoma


74 Follow-Up Strategy in Follicular Thyroid Cancer


75 Radionuclide Imaging and 131I Therapy in Follicular Thyroid Carcinoma


76 PET/CT in Follicular Cancer Including Hürthle Cell Cancer


77 Follicular Thyroid Cancer: Special Aspects in Children and Adolescents



78 External Radiation Therapy of Follicular Carcinoma


79 Determinants of Prognosis of Follicular Thyroid Carcinoma


PART VI. VARIANTS OF THYROID CANCER


80 Aggressive Variants of Papillary Thyroid Carcinoma and Poorly Differentiated Carcinoma


81 Miscellaneous and Unusual Tumors of the Thyroid Gland  


82 Pathology of Miscellaneous and Unusual Tumors of the Thyroid Gland


PART VII. UNDIFFERENTIATED TUMORS:  MEDULLARY THYROID CARCINOMA



83 Clinical Aspects of Medullary Thyroid Carcinoma



84 Cytology and Pathology of Medullary Carcinoma




85 Medullary Carcinoma of the Thyroid: Surgical Management



86 Radionuclide Imaging of Medullary Carcinoma


87 PET/CT in Medullary Thyroid Cancer


88 Radiation Therapy in Medullary Cancer


89 Medullary Carcinoma of the Thyroid: Chemotherapy


90 A Comparison of the ATA, NCCN, ETA, and BTA Guidelines for the Management of Medullary Thyroid Cancer


PART VIII. UNDIFFERENTIATED TUMORS:  THYROID LYMPHOMA


91 Thyroid Lymphoma


92 Pathology of Lymphoma of the Thyroid


93 PET/CT in Lymphoma and Lymphoma of the Thyroid


PART IX. UNDIFFERENTIATED TUMORS: ANAPLASTIC THYROID CANCER


94 Anaplastic Thyroid Carcinoma: Clinical Aspects


95 Surgical Management of Anaplastic Thyroid Carcinoma



96  Pathology of Anaplastic Carcinoma


97 PET/CT in Anaplastic Cancer of the Thyroid


98 Anaplastic Thyroid Cancer


99 Chemotherapy for Anaplastic Thyroid Cancer


100 Anaplastic Thyroid Carcinoma:  Prognosis


PART X. NEW FRONTIERS AND FUTURE DIRECTIONS


101 Advances in Radiation Therapy


102 New Approaches in Nuclear Medicine for Thyroid Cancer


103 124I in Differentiated Thyroid Cancer


104 Future Directions for Advanced Thyroid Cancer Therapy


105 Potential Approaches to Chemotherapy of Thyroid Cancer in the Future



PART XI. Additional Resources



106 Prophylaxis against Radiation Exposure from Radioiodine



107 Low Iodine Diets  



108 Appendix A: Books and Manuals



109 Appendix B: Additional Sources of Information: Support groups, Websites and additional information



110 Appendix C: Forms and Instructions for Patients Treated with Radioactivity