Thyroid Eye Disease

Raymond S. Douglas, MD, PhD, studied at the University of Pennsylvania and subsequently completed his residency in ophthalmology at the Scheie Eye Institute, University of Pennsylvania and his fellowship in orbital facial plastic and reconstructive surgery at the Jules Stein Eye Institute, University of California, Los Angeles. He is currently Associate Professor of Ophthalmology and Visual Sciences and a specialist in eye plastic, orbital, and facial cosmetic Surgery at the University of Michigan, Kellogg Eye Institute. Dr. Douglas' particular interests include orbital surgery, especially minimally invasive surgery, and decompressions for thyroid-associated eye disease; cosmetic facial surgery; and post-cancer reconstruction, including Mohs surgery.

Allison N. McCoy, MD, PhD, undertook her medical training at Duke University, Durham, North Carolina and also gained a doctorate in Neurobiology from the same university. Between 2008 and 2011 she served an Ophthalmology Residency at the Wilmer Eye Institute, Baltimore, and she is currently a Fellow in Eye Plastic, Orbital, and Facial Cosmetic Surgery. Dr. McCoy has been involved in a number of research projects and has been the recipient of the Neil Miller Research Grant Award, the Michael Boland Research Grant Award, the Mitchell Prize for Resident Research, and a Heed Fellowship. She is the author of 15 peer-reviewed publications.

Shivani Gupta, MD, MPH is an Eye Plastic, Orbital and Facial Cosmetic Surgery Lecturer in the Department of Ophthalmology and Visual Sciences at the University of Michigan. Her special interests include orbital surgery, cosmetic facial surgery including fillers and Botox injections, eyelid and lacrimal disorders, post-cancer reconstruction including Mohs' surgery.

This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid-associated eye diseases (TED). Thyroid-Associated Eye Disease can be read in its entirety to give a perspective of the field, but also considered as a reference as clinical questions arise. The goal is to deliver data- driven guidance and discreet approaches and suggestions useful for clinical practice and decision making.

Advances in diagnostic evaluation, including autoantibody assessment, are reviewed, and the diagnostic features of euthyroid TED are also discussed. All relevant aspects of treatment are covered, from the use of radioactive iodine, long-term medical therapy, and surgical thyroidectomy through to the treatment of active TED by steroids and novel biologics and the role of minimally invasive surgery. Numerous supporting images are included, and helpful checklists will aid the practitioner in treatment decision making.

Table of Contents

Chapter 1 Diagnosis and Endocrine Management of Graves' Disease

George J. Kahaly

Chapter 2 Natural History of Thyroid Eye Disease

Peter J. Dolman

Chapter 3 Emerging Role of Fibrocytes in the Pathogenesis of Thyroid Eye Disease

Terry J. Smith

Chapter 4 Management of Hyperthyroidism and the Effects on Thyroid Eye Disease

Fatemeh Rajaii, Shivani Gupta, and Raymond S. Douglas

Chapter 5 Smoking and Prevention of Thyroid Eye Disease

Wilmar M. Wiersinga

Chapter 6 Nutrition and Supplements in Thyroid Eye Disease

Claudio Marcocci and Francesca Menconi

Chapter 7 Pregnancy and Childhood Thyroid Eye Disease

Andrew G. Gianoukakis, Teeraun Jirajariyavej, Rebecca A. Hicks, Jennifer K. Yee

Chapter 8 Medical Management of Mild and Moderate to Severe Thyroid Eye Disease

Lucy Clarke and Petros Perros

Chapter 9 Management of Severe Thyroid Eye Disease and Use of Biological Agents

Mario Salvi, Richard L. Scawn, Roman Farjardo, Bobby S. Korn, Don O. Kikkawa

Chapter 10 Strabismus in Thyroid Eye Disease

Bokkwan Jun and Prem S. Subramanian

Chapter 11 Customized Minimally Invasive Orbital Decompression for Thyroid Eye Disease

Shivani Gupta, Allison N. McCoy, and Raymond S. Douglas

Chapter 12 Non-Invasive, Minimally Invasive and Surgical Pearls for Cosmetic Rejuvenation of the Thyroid Eye Disease Patient

Robert Goldberg and Daniel B. Rootman

Chapter 13 Psychological Disturbances in Thyroid Eye Disease

Sally Liu Baxter, Richard L. Scawn, Bobby S. Korn, Don O. Kikkawa