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Pathobiology of Cancer Regimen-Related Toxicities
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Artikel-Nr:
9781489990709
Veröffentl:
2015
Einband:
Paperback
Erscheinungsdatum:
25.06.2015
Seiten:
304
Autor:
Dorothy M. Keefe
Gewicht:
464 g
Format:
235x155x17 mm
Sprache:
Englisch
Beschreibung:
The contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treatment success and physiological cost. In the second segment of the book, the most current thinking around the pathobiology of specific, common, and representative toxicities is presented by leading researchers and translational scientists. The final portion of the book discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions.
This book defines the scope, impact and behavior of cancer regimen-related toxicities and frames the balance between treatment success and physiological cost. Covers pathobiology of common toxicities and strategies for development of effective interventions.
Defines the scope, impact and behavior of cancer regimen-related toxicities
Preface.-Epidemiology and outcomes of regimen-related toxicities.- The biological basis for differences in normal tissue response to radiation therapy and strategies to establish predictive assays for individual complication risk.- The bystander effect: Ionizing radiation-induced non-targeted effects: Evidence, mechanism and significance.- The role of genes on the metabolism of chemotherapeutic agents and their impact on toxicity.- Animal models of regimen-related toxicities.- Nausea and Vomiting.- Mucositis.- Dermatitis and Alopecia.- Fibrosis.- Myelosuppression.- Neuropathy.- Fatigue.- Xerostomia.- Osteonecrosis.- Conclusions and therapeutic opportunities.- Index.