Microfluidic Chip-Capillary Electrophoresis Devices

Dr. Ying Sing Fung received his BSc and MPhil from the University of Hong Kong, Hong Kong SAR, China, in 1975 and 1977, respectively, and his PhD from the Imperial College of Science, Technology and Medicine, University of London, United Kingdom, in 1980. He is currently associate professor in the Department of Chemistry at the University of Hong Kong. He has been a member of the editorial board of Journal of Chemical Education (Chinese Chemical Society) and Journal of Biochemical and Biophysical Methods (Elsevier Science, the Netherlands). He holds four patents and has authored or co-authored 12 books and reviews, more than 130 journal articles, and 290 conference papers.

Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Chip-Capillary Electrophoresis Devices broadens the scope of chemical analysis, particularly in the biomedical, food, and environmental sciences.

Microfluidic Chip-Capillary Electrophoresis: Expanding the Scope of Application for On-Site Analysis of Difficult Samples. Instrumentation and Facilities I: Fabrication of Microfluidic Chip-Capillary Electrophoresis Device. Instrumentation and Facilities II: Manipulating Nanofluids for Desired Operations to Achieve Intended Application by MC-CE Device. Single-Channel Mixing: Extending Analytical Range to Handle Samples with High Analyte Variation for Profiling Urinary Organic and Inorganic Anions. Dual-Channel Mixing: Standard Addition by Dual-Channel Continuous Flow Mixing for Assay of Complex Nephrolithiasis Biomarkers in Urine. Sample Cleanup and Analyte Enrichment: Integrating MIP/SPE with ME-MC-CE Device to Enhance Sample Cleanup and Multidimensional Analyte Enrichment for Hourly Determination of Atmospheric Carbonyl Compounds. Enhancing Separation Efficiency: On-Chip Multidimensional Separation and Determination of Urinary Proteins by MC-CE Device. Improving Detection Selectivity: MC-CE Device Integrated with Dual Opposite Carbon-Fiber Microdisk Electrodes Detection for Determining Polyphenols in Wine. Enhancing Detection Versatility: MC-CE Device with Serial Dual-Electrode Detection for Determining Glutathione Disulfide and Glutathione in Pharmaceutical Supplement. Detecting Optically Inactive Analyte: MC-CE Device Integrated with QDs/LIF Detection for Determination of Acrylamide in Food. Quantum Dots-Enhanced Fluorescence Detection: Immobilized Quantum Dots for Laser-Induced Fluorescence Detection of Organophosphorus Pesticides in Vegetables. On-Site Assay by Portable UV Detector: MC-CE Device for Authenification of Chinese Medicine. On-Chip Binding Assay: MC-CE Device Integrated with Multisegment Circular-Ferrofluid-Driven Micromixing Injection for Assay of Free Bilirubin and Albumin Residual Binding Capacity for Bilirubin. Counting Organelles: Direct Counting of Mitochondrial Numbers. Indirect Assessment of Organelles in Cell Extract: Determination of M