Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis

The eleventh monograph and meeting of the Foundation on "Hormon al Control of the Hypothalamo-Pituitary-Gonadal Axis" was held in October 1983 at the Weizmann Institute of Science. This monograph honors the memory of Professor Hans R. Lindner, a productive and innovative scientist greatly respected and admired by his col leagues. When addressing the opening session I remarked that my impres sion of the Weizmann Institute was one or two large buildings hous ing the various departments. This was my first visit to Israel and I was overwhelmed by the beautiful semi-tropical gardens of the in stitute, in a setting of shrubs and trees, orange groves and flow ers. Sited among this seventy-five acres are over fifty buildings and residential areas for the staff and visiting scientists. I saw pictures of this area when Dr. Chaim Weizmann founded in 1934, the Daniel Sieff Research Institute, the forerunner of the Weizmann In stitute. The site was sand dunes without a blade of grass. That the desert shall bloom is illustrative of the progress made in Is rael. The topics of the monograph are grouped into twelve sections.

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Neuroendocrine Control of Gonadotropin Secretion.- Role of Peptides in the Control of Gonadotropin Secretion.- Molecular Aspects of the Release of Luteinizing Hormone Releasing Hormone (LHRH) from Hypothalamic Neurons.- Role of Peptides in the Regulation of Gonadotropin and Prolactin Secretion.- Estrous Cycle Dependent Modulation of Muscarinic Cholinergic Receptors in the Hypothalamus and Adenohypophysis.- Molecular Aspects of GnRH Biosynthesis, Release, and Degreadation.- Hormones and Other Messenger Molecules: An Approach to Unity.- Regulation of the Synthesis, Release and Action of Hypothalamic Luteinizing Hormone Releasing Hormone.- Degradation of LH-RH.- Degradation of Luteinizing Hormone-Releasing Hormone by Rat Pituitary Plasma Membrane Associated Enzymes.- GnRH Receptors and Action in the Pituitary.- GnRH Receptors: Identification, Localization, and Implications for Biological Function.- Physiological Regulation of Pituitary GnRH Receptors.- GnRH Recpetor Microaggregation: Regulation of Gonadotropin Release, GnRH Receptors, and Gonadotrope Responsiveness.- Secretory Processes in the Pituitary.- Recent Progress in Cell Biology of Secretory Process in Anterior Pituitary Cells.- Fluidity of Gonadotropin Storage in Cycling Female Rats.- Regulation of Peptide Hormone Receptors in the Pituitary-Gonadal Axis: Receptors to Gonadotropins and Gonadotropin Releasing Hormone.- Gonadotropin Antagonists.- Strategies for the Inhibition of Gonadotropin Action.- The Role of Carbohydrate Moiety of Gonadotropin Molecule in Transduction of Biological Signal.- Endocrine Regulation of Ovarian Functions.- Intraovarian Regulation of Follicular Granulosa Cell Differentiation.- Calcium: A Cellular Mediator of Luteolysis.- New Perspectives on the Endocrine Regulation of the Rabbit CorpusLuteum.- Secretion and Action of Steroids in the Luteal Cell.- Hormones in Antral Fluid and the Regulation of Ovarian Function.- Regulation of Oocyte Maturation.- Mechanisms involved in the Follicular Rupture in the Rat.- Prolactin.- The Role of Cell-Cell Communication in Neuropeptide-Stimulated and Dopamine-Inhibited Prolactin Release.- Modulation of Prolactin Secretion at the Pituitary Level: Involvement of Adenylate Cyclase.- Hormones and Gene Expression.- Hormonal Regulation of Casein in Gene Expression in Normal and Transformed Mammary Cells.- In Vivo Regulation by Estradiol of the Messenger RNAs Encoding LH and FSH Subunits and the Secretion of Gonadotropins.- Regulation of Testicular Function.- Follicle Stimulating Hormone Regulation of Phosphodiesterase and Cell Response.- Regulation of Steroidogenic Activities in Leydig Cells by LH and an LHRH Agonist.- Extrapituitary Effects of GnRH.- Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone.- The Biological Actions of 'Testicular LHRH'.- Luteinizing Hormone-Releasing Hormone Independently Stimulates Cytodifferentiation of Granulosa Cells.- Action of LHRH Analogues on Rat Leydig Cells In Vitro: Effects on Cyclic AMP, Ca2+, Cholesterol Side Chain Cleavage and Cell Size.- Phospholipid Turnover in Gonadotropin-Releasing Hormone Target Cells: Comparative Studies.- Interaction of Opiates and Gonadotropins.- Relation of Endogenous Opiates to Secretion of Gonadotropins.- GnRH analogs: Clinical Uses in the Management of Fertility and Cancer.- Structure-Function of LH-RH Analogs and Design Applications to Other Peptide Systems.- Medical Castration with LHRH Agonists and the Need for Combined Treatment with an Antiandrogen in Prostate Cancer.- Potential Uses of LHRH and Analogues: Clinical Implications.-Application of GnRH for Induction of Ovulation in Anovulatory Menstruating Women.- Pulsatile Administration of GnRH in Hypothalamic Amenorrhea.- On the Mode of Action of an LHRH Agonist in Man and Its Potential Use as Contraceptive.- Hypothalamic-Pituitary-Gonadal Axis: Concluding Remarks.