Reproductive Processes and Contraception

This monograph represents the eighth sponsored by the International Society for Biochemical Endocrinology. The topics should be of interest to basic research scientists, medical practitioners, and students of repro ductive biology. It complements our monograph published in 1979 on Structure and Function of the Gonadotropins. The monograph is organized in ten topic areas relative to the general theme of reproduction and contraception. There are several chapters in each area. Obviously, all aspects of each area could not be covered. An attempt was made to seek interesting basic research ideas and concepts that might in the future be applicable to fertility regulation. The topics are: interactions in gonadotropin regulation; GnRH analogues as contra ceptive agents; receptors in cellular localization of hormones; uterine and mammary receptors; germ-cell regulation and secretory proteins; control mechanisms and metabolic regulations; hCG peptides and anti sera as antifertility agents; ieutinization, oocyte maturation, and early pregnancy; steroids and cell growth; and finally, prostaglandins and cell function. The studies encompass many disciplines and techniques in anatomy, physiology, biochemistry, and endocrinology in animals and humans, both in vitro and in vivo. A conference of contributors was held in Maine at the Asticou Inn in Northeast Harbor during the week of September 9-13, 1979. The chapters as written for the monograph were presented for discussion by the participants, who were selected for their knowledge of, and contri butions to, this area of scientific investigation.

Springer Book Archives

I Interactions in Gonadotropin Regulation.- 1 Control of Gonadotropin and Prolactin Secretion in Rhesus Monkeys and Rodents.- 2 Regulation of LH-RH Secretion by Gonadal Steroids and Catecholamines.- 3 Sensitivity of Pituitary Gonadotropic Cells and Gonads to Hormones.- II GnRH Analogues as Contraceptive Agents.- 4 Induction of Menstruation Following Subcutaneous Injection of LH-RH and Intranasal Administration of [d-Ser(TBU)6 des-Gly-NH210]LH-RH Ethylamide after Ovulation in Normal Women.- 5 Antifertility Effects of LH-RH and Its Agonists.- 6 Fertility and Antifertility Effects of LH-RH and Its Agonists.- III Receptors in Cellular Localization of Hormones.- 7 Stable and Specific Tracers.- 8 Specific Inhibitors of Androgen Binding to the Androgen-Binding Protein (ABP).- 9 Profiles of Target-Cell Prolactin and Adrenocorticotropin during Lactational Diestrus.- 10 Gonadotropin-like Immunoreactivity in the Rat Ovary: Ultrastructural Localization in the Granulosa, Theca, and Lutein Cells.- IV Uterine and Mammary Receptors.- 11 Hormonal Modulation of Progesterone Receptors.- 12 Hormonal Control of Steroid Receptors in Human Endometrium during the Menstrual Cycle.- 13 Parturition, Lactation, and the Regulation of Oxytocin Receptors.- V Germ-Cell Regulation and Secretory Proteins.- 14 Control of Spermatogonial Multiplication.- 15 Secretory Proteins in the Male Reproductive System.- 16 Monitoring the Metabolic Rate of Germ Cells and Sperm.- 17 Study of a Glycoprotein Produced by the Rat Epididymis.- VI Control Mechanisms and Metabolic Regulation.- 18 The Use of Isopropyl-N-phenylcarbamate as a Potential Contraceptive: Control of Meiotic Maturation.- 19 Interaction between Prolactin and Gonadotropin Secretion.- 20 Interactions among LH, FSH, PRL, LH-RH, and Sex Steroids in the Control of Testicular LH, FSH, and PRL Receptors in the Rat.- 21 Inhibition of Testicular Androgen Biosynthesis by Treatment with LH-RH Agonists.- 22 Gonadotropic Stimulation of Enzymes Involved in Testicular Growth.- 23 Uterine Diamine Oxidase: A Marker for Progestin Action.- VII hCG Peptides and Antisera as Antifertility Agents.- 24 Specific Antisera to Human Choriogonadotropin.- 25 Development of Specific Antisera for Human Chorionic Gonadotropin.- 26 Isolation and Characterization of an "hCG"-like Protein from Bacteria.- VIII Luteinization, Oocyte Maturation, and Early Pregnancy.- 27 Comparative Approach to Mechanisms in the Maintenance of Early Pregnancy.- 28 Porcine and Human Ovarian Nonsteroidal Follicular Regulators: Oocyte-Maturation Inhibitor, Luteinization Inhibitor, Luteinizing-Hormone-Receptor-Binding Inhibitor, Follicle-Stimulating-Hormone-Binding Inhibitor, and Inhibin F.- IX Steroids and Cell Growth.- 29 Estrogen-Induced Growth of Uterine Cells: Evidence for Involvement of Surface Membranes, Calcium, and Proteinase Activity.- X Prostaglandins and Cell Function.- 30 Prostaglandin-Induced Luteolysis in the Superluteinized Rat Ovary.- 31 Role of Prostaglandins in Leydig-Cell Stimulation by hCG and Leydig-Cell Function.