Structure and Function of the Gonadotropins

In September of 1977 scientists from many countries met at the Asticou Inn in Maine to present and discuss papers written especially for this monograph. The presentations were informal and directed to the special interests of the audience in order to generate discussions. The authors, many of whom are pioneers and leaders in their field, then had the oppor tunity to revise their contributions, which were brought together with the edited discussions to form this volume. The basic research studies presented here are important because of the essential role of gonadotropins in regulating the ovary and testis. This monograph will therefore be of interest to those concerned with fertility regulation, population control, possible new methods for contraception, and to those concerned with reproduction in domestic animals. Re searchers in other fields may find this monograph useful, as it has been de termined that gonadotropins are secreted by many tumors and are im plicated in many cancers. Human choriogonadotropin also seems to be found in most, if not all, cells of the human body. The significance of this, however, is unknown.

Springer Book Archives

1 Mechanism of Action of Gonadoptropins and the Regulation of Gene Expression.- 2 Chemical Approaches to the Structure-Function Relationships of Luteinizing Hormone (Lutropin).- 3 Structural and lmmunochemical Properties of Human Choriogonadotropin.- 4.Glycoprotein Hormones: Some Aspects of Studies of Secondary and Tertiary Structure.- 5 Autoradiographic Localization of FSH-Binding Sites on Sertoli Cells and Spermatogonia in Testes from Hypophysectomized Rats.- 6 Serum-Factor- and Prolactin-Induced Stimulation of DNA Synthesis by Nuclei Externalized from Mammary Tissue.- 7 Target Cell Prolactin.- 8 The Structure and Function of Follicle-Stimulating Hormone.- 9 The Biosynthesis of Prolactin.- 10 The Biosynthesis of Chorionic Gonadotropin and Placental Lactogen in First- and Third-Trimester Human Placenta.- 11 The Interaction of Follitropin (FSH) with Membrane-Bound and Solubilized Gonadal Receptors and Adenylate Cyclase.- 12 Drug Effects on Lutropin Action.- 13 Effects of FSH and LH on RNA Synthesis in the Testis: Role of Ornithine Decarboxylase.- 14 Regulation of Gene Expression in the Nucleus by Gonadotropins.- 15 Glycoprotein Hormones and Their Subunits- Immunological and Biological Characterization.- 16 Biochemical and Biological Properties of Fish Gonadotropins and Their Subunits: Comparison with Mammalian Hormones.- 17 Molecular Aspects of the Subunit Assembly of Glycoprotein Hormones.- 18 Biological and Immunological Distinctions between Pituitary and Serum LH in the Rat.- 19 Parallels in the Modes of Action of Peptide and Steroid Hormones: Membrane Effects and Cellular Entry.- 20 Timing and Sites of Testicular Effects of FSH in Vivo.- 21 Leydig-Cell Responsiveness to LH-Hcg Stimulation: Mechanisms of hCG- and Steroid-Induced Refractoriness.- 22 FSH and theSertoli Cell.- 23 Immunocytochemical Demonstration of Endogenous Membrane and Intracellular Gonadotropin-Binding Sites in the Fetal Rat Testis.- 24 Gonadotropin-Target Cell Interactions: A Model Based on Morphological Localization.- 25 Localization of Human Chorionic Gonadotropin in Lysosomes of Ovine Luteal Cells.