Inflammation, Oxidative Stress, and Cancer

Ah-Ng "Tony" Kong, Ph.D., is a distinguished professor (PII), Glaxo Endowed Chair Professor of Pharmaceutics, and director of the Graduate Program in Pharmaceutical Sciences at Rutgers, the State University of New Jersey. He is also the director for the Center for Pharmacogenetics and Pharmacogenomics at Rutgers University. Dr. Kong has published more than 200 original research papers, review articles, and book chapters. He has chaired and given presentations in many national and international symposia and conferences and is currently serving on the board of 15 international journals. His research areas are in dietary phytochemicals (signaling and gene expression, nutrigenomics, cancer chemoprevention); animal tumor models of the prostate, colon, and skin; epigenetics/epigenomics; oxidative/redox/inflammatory stress response; Nrf2-mediated nuclear transactivation and signaling; and pharmacokinetics and pharmacodynamics of phytochemicals.

Increasing scientific evidence suggests that most diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors such as diet. This book examines the latest developments on the cancer-preventive effects of various dietary phytochemicals working through anti-oxidative and anti-inflammatory response-related mechanisms. The book is divided into sections covering inflammation, oxidative stress, phytochemicals, and cancer; signal transduction, molecular targets, and biomarkers; and various classes of phytochemicals, including vitamins, garlic compounds, and other dietary phytochemicals and herbal medicines.

Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer. Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals. Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals. Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective. Section V: Omega-3 and Omega-6 Fatty Acids. Section VI: Flavonoids and Polyphenols. Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates. Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention. Section IX: Epigenetics and Chronic Inflammation. Index.