Intraovarian Control Mechanisms

Recently intraovarian control of steroidogenesis and oocyte maturation has become a subject of interest. Non steroidal sub stances secreted locally by the ovarian follicle and corpus luteum have been implicated in control of oocyte maturation follicular ma turation and steroidogenesis as well as luteal function. In addi tion some ovarian polypeptides such as inhibin F (folliculostatin) leave the ovary and act as modulators of pituitary function which in turn regulates ovarian function by exhibiting changes in follicle stimulating hormone secretion in response to changes in inhibin. It was desired to see how these intraovarian regulators act to control ovarian function. In addition it was of interest to see what the chemical nature of these intraovarian regulators is. To achieve these ends a meeting was held at the Villa Serbelloni in Bellagio situated overlooking Lake Como. Leaders in this field were invited and asked to vigorously discuss the subject of intraovarian control mechanisms. Their manuscripts comprise this volume. C. P. Channing S. J. Segal CONTENTS Maturation, Morphology, and Endocrine Function of the Ovarian Follicle 1 Lars Bjersing Role of Ovarian Inhibin (Folliculostatin) in Regulating FSH Secretion in the Female Rat 15 Neena B. Schwartz Purification, Characterization, and In Vitro Produc tion of Inhibin 37 F. H. de Jong, E. H. J. M. Jansen, W. P. Hermans, and H. J. van der Molen Hormonal Control of Inhibin Secretion . 53 Larry D. Anderson and Dennis J.

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Maturation, Morphology, and Endocrine Function of the Ovarian Follicle.- Role of Ovarian Inhibin (Folliculostatin) in Regulating FSH Secretion in the Female Rat.- Purification, Characterization, and In Vitro Production of Inhibin.- Hormonal Control of Inhibin Secretion.- Characteristics of Inhibin: A Comparative Study Using Bull and Human Seminal Fluids and Porcine Follicular Fluid.- Partial Purification of Porcine Follicular Fluid Gonadostatin.- Purification of Gonadostatin from Bovine Seminal Plasma (BSP).- Properties of Follicle Stimulating Hormone Binding Inhibitors Found in Physiological Fluids.- Oocyte Maturation Inhibitor: A 1981 Perspective.- Meiotic Arresting Substance Separated from Porcine Ovarian Granulosa Cells and Hypothetical Arresting Mechanism of Meiosis.- Role of Cumulus Cells in Oocyte Maturation.- Actions of Hormones and Other Factors Upon Oocyte Maturation.- Intraovarian Actions of GnRH.- Regulation of Ovarian Granulosa and Luteal Cell Functions by Gonadotropin Releasing Hormone and Its Antagonist.- LH-Binding Inhibitors from the Corpus Luteum.- Characterization of LH/hCG Receptor Binding Inhibitor in Corpora Lutea of Human and Sheep Ovaries.- Regulation of Cholesterol Acquisition and Utilization in the Corpus Luteum.- Some Observations that May Pertain to Structure-Function Relationships of hCG?.- Stimulation of Granulosa Cell Maturation by Follicular Fluid.- Intraovarian Regulation of Granulosa-Cell Replication.- Comparison of Granulosa and Sertoli Cells at Various Stages of Maturation: Similarities and Differences.- List of Contributors.- Author Index.