Scleroderma

Foreword.- Preface.- Historical Perspective.-Therapeutic evolution: a professor's view.- Overview: Epidemiology, Genetics and Classification.-Epidemiology and Environmental Risk Factors.- Genetic Factors.- Disease Subsets in Clinical Practice.-Evolving Concepts of Diagnosis and Classification.- Disease Classification using Molecular Signatures.-Localized Scleroderma.- Juvenile Systemic Scleroderma.-Scleroderma Mimics.- Localized Forms of Scleroderma in Adults.-Overview: Integrated Pathogenesis.- Immunological Mechanisms.-Innate Immunity.- Autoantibodies in Pathogenesis.- The Clinical Aspects of Autoantibodies.- Mechanisms of Vascular Disease.-Vascular Biomarkers.- Mechanisms of Fibrosis.- Fibrosis: Insights from the stiff skin syndrome.- Biomarkers of Fibrosis.- Overview of Animal Models.-Overview: Cardiovascular Manifestations and Management.-Raynaud Phenomenon.-Nailfold Capillaroscopy.- Systemic Vascular Disease.- Scleroderma Renal Crisis.- Cardiac Involvement.-Erectile Dysfunction.-Overview: Pulmonary manifestations and management.-Clinical Assessment of Lung Disease.- Computerized Tomography of Interstitial Lung Disease.-Treatment of interstitial lung disease.-Clinical Assessment of Pulmonary Hypertension.-Treatment of Pulmonary Hypertension.- Complex Challenges of Pulmonary Hypertension.- Overview: Gastrointestinal Manifestations and Management.- Upper Gastrointestinal Tract.-Small and Large Intestinal Involvement.-Evaluation and Management of Skin Disease.-Skeletal Muscle Involvement.- Tendons, Joints and Bone.- Pregnancy.-Overlooked Manifestations.- Principles of Management.-Immunomodulatory Therapies.-Cell-Based Therapies.- Investigative Approaches to Drug Therapy.-Complementary and alternate medicine approaches.-Physical and occupational therapy.- Evaluation and Management of Psychosocial Issues.-Issues in Clinical Trial Design.- Measuring Disease Activity.- Patient Reported Outcomes.