Hereditary Colorectal Cancer

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. This is the first book to cover Hereditary nonpolyposis colorectal cancer, also known as the Lynch syndrome, in one comprehensive text.

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as the Lynch syndrome, has not yet been covered in one comprehensive text The basic and clinical knowledge related to hereditary colorectal cancer is expanding and evolving rapidly A panel of worldwide experts address the issues surrounding hereditary colorectal cancer

History.- History: Familial Adenomatous Polyposis.- Historical Aspects of Lynch Syndrome.- Basic Sciences and Genetics.- Molecular Genetics of Familial Adenomatous Polyposis.- DNA Mismatch Repair.- Basic Sciences and Genetics: Hamartomatous Polyposis.- Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition.- MUTYH-Associated Polyposis.- Polymorphic Variation and Risk of Colorectal Cancer.- Pathology.- The Pathologist and the Phenotype of Hereditary Colorectal Cancer.- Clinical Science: Familial Adenomatous Polyposis.- Genotype Phenotype Correlation in Familial Adenomatous Polyposis.- Surgery for Familial Adenomatous Polyposis.- Duodenal Adenomas in Familial Adenomatous Polyposis.- FAP-Associated Desmoid Tumours.- Attenuated Familial Adenomatous Polyposis: Diagnosis, Management, and Future Prognosis.- Clinical Science: Hereditary Nonpolyposis Colorectal Cancer.- An Overview of the Lynch Syndrome (Hereditary Non-polyposis Colorectal Cancer).- Surgical Management in Lynch Syndrome.- Extracolonic Tumors.- Surveillance.- Clinical Science: MYH Associated Polyposis.- MUTYH-Associated Polyposis.- Clinical Science: Hamartomatous Polyposis.- Peutz-Jeghers Syndrome.- Clinical Aspects of Juvenile Polyposis.- Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients.- Clinical Science: Hyperplastics Polyposis.- Hyperplastic Polyposis.- Genetic Counseling.- Genetic Counseling Overview.- Across Culture and Health Systems: Europe.- Across Culture and Health Systems: Asia (Hong Kong).- Across Culture and Health Systems: Asia (Japan).- Across Culture and Health Systems: Africa.- Across Culture and Health Systems: Argentina.- Genetic Counselling Across Culture and Health Systems: Australia.- Across Culture and Health Systems: Korea.- Across Culture and Health Systems: America.- Psychosocial Aspects of Hereditary Colorectal Cancer.- Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancers.- Chemoprevention.- Chemoprevention for Inherited Colorectal Cancer.- Registries.- Registries.- Erratum.- Erratumto: Chapter 22: Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients.