Pathology Reviews · 1989

on the theories of Planck and Einstein. Rather, until The concept that human disease is a specialized branch of biology is universally accepted today, but in the mid-20th century, the accretion of individual historical perspective, is actually of recent origin. At examples of the biological nature of disease processes provided the framework for an evolutionary change in one time, the heliocentric theories of astronomy and the metallurgic transmutations of alchemy had their thinking. The new psychological and philosophical milieu provided the basis for an unprecedented accel counterparts in magical and vitalistic approaches to eration in the pace of biomedical research. It is clear human disease. Any relation between disease of humans and that of animals was not only unacceptable that the biological revolution of the last 35 years was made possible not only by technological advances and intellectually, but abhorrent theologically. Humans (and their diseases) were unique, and biology was the innovative analytical methods, but also by an intellec domain of those who studied animals and plants. tual emphasis on the unity of biological processes. The unification of biology and the study of human High school students are now aware that there is much disease, though begun some centuries ago, was con to be learned about the human condition by studying spicuously stimulated by the work of Darwin, and bacterial DNA, the chloroplasts of green leaves, or the reached its full flower in this century. For example, kinetics of enzymes in vitro.

Springer Book Archives

Section I: Cell and Metabolic Disorders.- Mammalian Glucocerebrosidase: Implications for Gaucher's Disease.- Human Amyloidosis, Alzheimer Disease and Related Disorders.- Receptor-Mediated Endocytosis and Intracellular Processing of Insulin: Ultrastructural and Biochemical Evidence for Cell-Specific Heterogeneity and Distinction from Nonhormonal Ligands.- Gastrin-Releasing Peptide (Mammalian Bombesin) Gene Expression in Health and Disease.- Morphology and Biochemistry of Bone Remodeling: Possible Control by Vitamin D, Parathyroid Hormone, and Other Substances.- Section II: Inflammation and Immunity.- Acute Inflammation and Microthrombosis Induced by Endotoxin, Interleukin-1, and Tumor Necrosis Factor and Their Implication in Gram-Negative Infection.- Role of T Helper Lymphocytes in Autoimmune Diseases.- Early Biochemical Events in Leukocyte Activation.- Nonimmunologic Mechanisms of Glomerular Injury.- The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation.- Section III: Tumor Biology.- The Role of Extracellular Proteases in Cell Proliferation and Differentiation.- Dietary and Nutritional Influences on Cancer: A Review of Epidemiologic and Experimental Data.- Section IV: Advances in Methodology.- Advances in Flow Cytometry for Diagnostic Pathology.- Transgenic Mice-A Gold Mine for Furthering Knowledge in Pathobiology.