Annual Plant Reviews, Volume 39, Functions and Biotechnology of Plant Secondary Metabolites

This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology (Annual Plant Reviews, Volume 3). This exciting new volume provides an up-to-date survey of the functions of plant secondary metabolites, their modes of action and their use in pharmacology as molecular probes, in medicine as therapeutic agents, and in agriculture as biorational pesticides. The possibilities to produce valuable natural products in plant cell and tissue culture and even in recombinant microorganisms are also reviewed. This carefully compiled new edition brings together chapters from some of the world s leading experts in plant secondary metabolites. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 40, Biochemistryof Plant Secondary Metabolism, Second Edition, Edited by M. Wink, is also available.

This brand new Annual Plant Reviews volume is the second edition ofthe highly successful and well-received Functions of PlantSecondary Metabolites and their Exploitation in Biotechnology(Annual Plant Reviews, Volume 3).This exciting new volume provides an up-to-date survey of thefunctions of plant secondary metabolites, their modes of action andtheir use in pharmacology as molecular probes, in medicine astherapeutic agents, and in agriculture as biorational pesticides.The possibilities to produce valuable natural products in plantcell and tissue culture and even in recombinant microorganisms arealso reviewed.This carefully compiled new edition brings together chaptersfrom some of the world's leading experts in plant secondarymetabolites. Completely revised and brought right up to date withmuch new information, this volume is an essential purchase foradvanced students, researchers and professionals in biochemistryphysiology, molecular biology, genetics, plant sciencesagriculture, medicine, pharmacology and pharmacy, working in theacademic and industrial sectors, including those working in thepesticide and pharmaceutical industries. Libraries in alluniversities and research establishments where these subjects arestudied and taught will need copies of this excellent volume ontheir shelves.* A companion volume Annual Plant Reviews Volume40, Biochemistryof Plant SecondaryMetabolism, Second Edition, Edited by M. Wink, is alsoavailable.

List of contributorsPreface1 IntroductionMichael Wink1.1 Ecological function of secondary metabolites1.2 Presence of defence and signal compounds at the right timeand place1.3 Molecular modes of action of SM1.4 Biotechnology and utilization of SM1.5 Conclusions2 Molecular Modes of Action of Defensive SecondaryMetabolitesMichael Wink and Oskar Schimmer2.1 Introduction2.2 Molecular modes of action - an overview2.3 Accumulation of defence and signal compounds in plants2.4 Animal responses: detoxification mechanisms andadaptations2.5 Concluding remarks3 Chemical Defence in Marine EcosystemsAnnika Putz and Peter Proksch3.1 Introduction3.2 Marine natural products in allelopathic interactions3.3 Chemical defence against fouling3.4 Chemical defences of marine invertebrates and algae againstconsumers3.5 Favoured allocation of defensive metabolites in vulnerableand valuable parts of marine invertebrates and algae3.6 The flexible response: stress-induced accumulation ofdefence metabolites and activation of protoxins3.7 Endosymbionts as sources for allelochemicals found in marineinvertebrates3.8 Conclusions and outlook4 Plant-Microbe Interactions and Secondary Metaboliteswith Antibacterial, Antifungal and Antiviral PropertiesJürgen Reichling4.1 Introduction4.2 Phytoalexins4.3 Antibacterial and antifungal agents of higher plants4.4 Secondary metabolites from higher plants with antiviralproperties4.5 Conclusions5 New Medical Applications of Plant Secondary MetabolitesJörg Heilmann5.1 Introduction5.2 Compounds with anticancer and chemopreventive activity5.3 Antiviral compounds5.4 Antimalarial drugs5.5 Anti-inflammatory drugs5.6 Antidepressant drugs5.7 Anti-ischaemic drugs5.8 Immunostimulatory drugs5.9 Conclusions6 Production of Natural Products by Plant Cell and OrganCulturesAugust-Wilhelm Alfermann6.1 Introduction6.2 Production of natural products by cell and organcultures6.3 Elicitation6.4 Increase/decrease of product yields by geneticmanipulation6.5 Biosynthetic pathways delineation using RNA-interference6.6 Mass cultivation of plant cell cultures6.7 Production of recombinant proteins by plants and plant cellcultures6.8 Production of plant natural products in microbes6.9 PerspectivesIndex