Targeting the Wnt Pathway in Cancer
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Beschreibung:
This book provides an overview of the Wnt pathway as a therapeutic target for cancer and discusses the preclinical development of inhibitors directed to upstream and downstream components of the pathway.
Chapter 1. An Introduction to Wnt Signaling
Paul Polakis
Chapter 2. Regulation of Wnt Secretion and Distribution
Xiaofang Tang Xiaolan Fan and Xinhua Lin
Chapter 3. Wnt Signaling in Stem Cells
Philipp C. Manegold, Jia-Ling and Teo Michael Kahn
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Chapter 4. Crosstalk of the Wnt Signaling Pathway
Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga
Chapter 5. Dysregulation of the WNT Pathway in Solid Tumors
Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss
Chapter 6. WNT/b-catenin Signaling in Leukemia
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada