This text is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of the nervous system. It covers the neurobiology of actin ranging from basic cellular organization and function to the roles of actin in the health and disease states of the nervous system. Its opening chapter presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in a cellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The latter section of the book then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested in investigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters.
Examining the interface between the actin cytoskeleton and the myriad issues fundamental to the understanding of the nervous system, this text covers actin's neurobiology, from its basic cellular organization and function to its roles in health and disease.
Introduces key issues linking the actin cytoskeleton to the nervous system
Chapter 1: Introduction to the Neurobiology of ActinGianluca GalloChapter 2: The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and FilopodiaGianluca GalloChapter 3: Regulation of Actin Filaments During Neurite Extension and GuidancePaul LetourneauChapter 4: Functions of Myosin Motor Proteins in the Nervous SystemDaniel M. SuterChapter 5: Microtubule-Actin Interactions During Neuronal DevelopmentKenneth A. Myers, Peter W. BaasChapter 6: Working with Actin: Methodological Approaches for the Study of Actin in NeuronsErik W. DentChapter 7: Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous SystemJeffrey D. HildebrandChapter 8: Actin Cytoskeletal Regulation in Neuronal MigrationM. Elizabeth Ross, Stanislav KholmanskikhChapter 9: Actin and Neuronal PolarityAnnette Gärtner, Carlos G. DottiChapter 10: Actin at the Synapse: Contribution to Pre and Post-synaptic FunctionsDezhi LiaoChapter 11: Actin and Diseases of the Nervous SystemBarbara W. Bernstein, Michael T. Maloney, James R. BamburgChapter 12: Signal Transduction Pathways: From Receptor to the Actin CytoskeletonCatherine Irene Dubreuil, David L. Van Vactor