The Physical Basis of Biochemistry

Kevin Hallock, Ph.D., is a researcher and instructor in the Department of Anatomy and Neurobiology at the Boston University School of Medicine in Boston, Masschusetts, where he teaches biostatistics, an graduate course on the science of disasters, and co-teaches biophysical chemistry and modeling courses with Dr. Bergethon. His research interests include the impact of antimicrobial peptide on phospholipid bilayers, solid-state NMR and magnetic resonance imaging characterization of crystalline solids, atherosclerotic plaque formation, magnetic resonance microscopy of arthropods, the impact of chronic Hg exposure on aging, and the role cell membrane biophysics play in the fundamental processes of neurophysics.Peter Bergethon, MD is the Head of the Neuroscience Interdisciplinary Modeling and Simulation Center (NIMS Center), the Laboratory for Intelligence Modeling and Neurophysics and a member of the faculty in both the Departments of Anatomy/Neurobiology and Biochemistry at Boston University School of Medicine. His research spirals around a core question: "What is the physical and systemic basis for creativity and intelligent behavior and how could such behavior be practically constructed or reconstructed?" Dr. Bergethon is also an active member of the American Academy of Neurology from which he received the Founder's Award , the Electrochemical, Biophysical, American Chemical Societies, the Society for Neuroscience and the American Society of Biochemistry and Cellular Biology.

The aim of this book is to ground students in the basic principles of biochemistry and molecular biophysics. It delves into developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies.

Grounds students in the basic principles of biochemistry and molecular biophysics 2.

PART I: Principles of Biophysical InquiryChapter 1Philosophy and Practice of Biophysical StudyChapter 2Overview of the Biological System Under Study - Descriptive ModelsChapter 3Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systemsChapter 4Probability and StatisticsPART II:FoundationsChapter 5Physical Principles: Energy - The Prime ObservableChapter 6Biophysical Forces in Molecular SystemsChapter 7An Introduction to Quantum MechanicsChapter 8Chemical PrinciplesChapter 9 Measuring the Energy of a System: Energetics and the First Law of ThermodynamicsChapter 10Entropy and the Second Law of ThermodynamicsChapter 11 Which Way Did That System Go? The Gibbs Free EnergyChapter 12The Thermodynamics of Phase EquilibriaPART III: Building a Model of Biomolecular StructureChapter 13Water: A Unique Structure, A Unique SolventChapter 14Ion-Solvent InteractionsChapter 15Ion-Ion InteractionsChapter 16Lipids in Aqueous SolutionChapter 17Macromolecules in SolutionChapter 18Molecular Modeling - Mapping Biochemical State SpaceChapter 19The Electrified InterphasePART IV: Function and Action Biological State SpaceChapter 20Transport and Kinetics: Processes Not at EquilibriumChapter 21Flow in a Chemical Potential Field: DiffusionChapter 22 Flow in an Electrical Field: ConductionChapter 23Forces Across MembranesChapter 24Kinetics - Chemical KineticsChapter 25 Bioelectrochemistry - Charge Transfer in Biological SystemsPART V: Methods for the Measuring Structure and FunctionChapter 26Separation and Characterization of Biomolecules Based on Macroscopic PropertiesChapter 27Determining Structure by molecular interactions with photons: Electronic SpectroscopyChapter 28Determining Structure by molecular interactions with photons: Scattering PhenomenaChapter 29Analysis of Structure - MicroscopyPART VI: Physical ConstantsPhysical Constants