Bio-Farms for Nutraceuticals
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Bio-Farms for Nutraceuticals

Functional Food and Safety Control by Biosensors
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Maria Teresa Giardi
881 g
260x183x24 mm
Advances in Experimental Medicine and Biology

MARIA TERESA GIARDI, PhD, is a Research Manager at the National Council of Research (CNR) in Rome, Italy. Her background is in organic-industrial chemistry, and she has extensive experience in molecular biology; modification of photosystem II to increase its resistance to high temperature and sensitivity to radiation; signal transduction in optical and electrochemical biosensors; protein stabilization and utilization in biosensor design, and analytical procedures in general. She is a referee for the US Department of Agriculture for industrial projects. She has worked in various research institutions and research and development companies both in Europe and the USA. She is a supervisor or coordinator of a number of national and international projects in the field of biosensors: European Agency Life V project, 20xx-2004; a European Space Agency project involving space flight in 2005; a NATO "linkage grant", dedicated to sensors based on plant and microrganisms.GIUSEPPINA REA, PhD, is a molecular biologist and is on the permanent staff of CNR-IC. She is an expert in the molecular mechanisms involved in plant defense responses and has many years of experience in plant molecular biology, biochemistry, biotechnology and protein engineering techniques. She is project monitor of the CNR project Biotechnological Applications of Oxygenic Photosynthetic Organisms in the Agro-food Field and Space Environment, and the EU projects Multibioplat and Sensbiosyn, aimed at producing bacteria and algae with improved photosynthetic performance to exploit them in biological farms for nutraceutical applications and biosensing elements in biosensor development. Her research activities are mainly focused on Chlamydomonas reinhardtii and Rhodobacter sphaeroides. She is advisor to several PhD students in Plant Biotechnology working in the fields of exobiology, nutraceutics and biosensors.BRUNO BERRA, PhD, received his academic degree in Chemistry from the University of Pavia, Italy. He is Professor f.r. of Biochemistry at the University of Milan and works at the Department of Molecular Sciences Applied to Biosystems in the Faculty of Pharmacy. During his active teaching career he taught Biochemistry, Molecular Biology, Nutrition Biochemistry and Cosmetology. His most important research areas include: isolation, fractionation, purification and analysis of glycolipids from brain, extranervous tissues and biological fluids; biochemical diagnosis of sphingolipidosis and follow-up of Gaucher's patients receiving enzyme replacement therapy; nutritional biochemistry with reference to fats and antioxidants; membrane component studies in spontaneous or induced degenerative processes, with particular reference to solid and tumor cells; skin biochemistry and molecular biology of the skin; and space biology. He is a member of numerous national and international scientific organisations including the Italian Society of Biochemistry (1957-2004), the Italian Society for Fat Research, the International Conference of Biochemistry of Lipids (ICBL), the Euro Fed Lipid, the American Oil Chemist's Society, and the American Society of Diabetes.
"Bio-Farms for Nutraceuticals" can be said to have been born of the NUTRA-SNACKS project within the Sixth Framework Programme Priority on Food Quality and Safety. One objective of NUTRA -SNACK S was to improve the nutritional and eating properties of ready-to-eat products and semi-prepared foodstuffs through better monitoring of the quality and safety of raw materials and the development of innovative processes along the production chain. Another main objective of the project was the production of ready-to-eat snacks with high nutraceutic activity. Seven research institutes and three companies in six European countries were involved in this effort. The co-operation resulted in the production of food having a high content of natural metabolites with the following beneficial health effects: anticancer, antilipidemic, anticholesterol, antimicrobial, antibacterial, antifungal, antiviral, antihypertensive, anti-inflamatory and antioxidant activities.
This book derives from the NUTRA-SNACKS project. One of the project's chief aims, reflected in this book, is to improve the properties of ready-to-eat products and semi-prepared foodstuffs through better monitoring of the quality and safety of raw materials.
Describes the efficacy and safety of some medicinal, nutraceutic herbs and plants
1. The Nutra?Snacks Project: Basic Research and Biotechnological Programs on NutraceuticsGiuseppina Rea, Amina Antonacci, Maya Lambreva, Andrea Margonelli, Cecilia Ambrosi and Maria Teresa GiardiAbstractRationale of the Nutra?Snacks ProjectTechnological InnovationsConclusion2. Overview of Diet?Gene Interactions and the Example of XanthophyllsBarbara Demmig?Adams and William W. Adams, IIIAbstractIntroduction: Overview of Diet?Gene Interaction in Human DiseaseA Case Study: Xanthophylls and Their Synergism with Other Dietary Factors in Human Health-Protection against Eye Disease and Other Chronic DiseasesDietary Sources of Zeaxanthin and Lutein and Their Potential Enhancement3. Therapeutic Potential of Dietary Polyphenols against Brain Ageing and NeurodegenerativeDisordersGiovanni Scapagnini, Calogero Caruso and Vittorio CalabreseAbstractIntroductionCurcuminCaffeic Acid Phenethyl EsterEthyl FerulateEpigallocatechin?3?GallateConclusion4. Plant Phenolics in the Prevention and Treatment of CancerKlaus W.J. Wahle, Iain Brown, Dino Rotondo, and Steven D. HeysAbstractEpidemiology of Plant Foods and Disease IncidenceAnticancer Phytochemicals in Foods, Beverages and SpicesClassification and Occurrence of Plant Phenolic CompoundsCellular Mechanisms Modified by Plant Phenolics That Can Reduce Carcinogenesis and Tumour ProgressionConclusion5. Endogenous Antioxidants and Radical ScavengersAngela Maria Rizzo, Patrizia Berselli, Stefania Zava, Gigliola Montorfano, Manuela Negroni, Paola Corsetto and Bruno BerraAbstractIntroductionEndogenous Antioxidant MoleculesReactive Oxygen Species: Always Bad?Conclusion6. A Nutritional Strategy for Reducing Disease and Obesity RisksTeresa Lavecchia, Paolo Petroni, Giuseppe Rodio and Riccardo PinaAbstractIntroductionThe Zone Diet Nutrition Strategy: General OutlineConclusion7. Dietary Phytochemicals and Human HealthJustyna Krzyzanowska, Anna Czubacka and WieslawOleszekAbstractIntroductionCarotenoidsPhenolic CompoundsPhytoestrogensPolyunsatured Fatty AcidsConjugated Linoleic AcidsTocopherols and TocotrienolsLimoneneAllicin and Diallyl DisulfideGlucosinolatesCapsacinoidsConclusion8. Bioactive Compounds from Northern PlantsAnja HohtolaAbstractIntroductionHow External Factors Influence the Biosynthesis of Secondary MetabolitesResearch and ExploitationExamples of Northern Plants Containing Bioactive CompoundsConclusion9. Nutraceutical Use of Garlic Sulfur?Containing CompoundsEleftherios Touloupakis and Demetrios F. GhanotakisAbstractIntroductionGarlic Chemical CompoundsGarlic Biological ActivitiesAlliin and AllicinGarlic AlliinaseGarlic SupplementsLayered Double HydroxidesAlginatesConclusion10. Genetic Engineering to Enhance Crop?Based Phytonutrients (Nutraceuticals) to Alleviate Diet?Related DiseasesAutar K. Mattoo, Vijaya Shukla, Tahira Fatima, Avtar K. Handa and Surender K. YachhaAbstractIntroductionDiet and Human DiseasesPhytonutrients and Antiproliferative ActivityGenetic Engineering to Improve Nutrient (Nutraceutical) Content in ProduceProteins and Amino AcidsCarotenoidsFolatesVitamin C (Ascorbate)PolyphenolicsTocopherolsIronConclusion11. Perspective for the Use of Genetic Transformants in Order to Enhance the Synthesis of the Desired Metabolites: Engineering Chloroplasts of Microalgae for the Production of Bioactive CompoundsUdo Johanningmeier and Dirk FischerAbstractIntroductionMicroalgae as Transgenic BioreactorsGenetic Engineering of Plant and Microalgal ChloroplastsExpression of Recombinant Proteins in C. reinhardtii ChloroplastsApplication to Food TechnologyConclusion12. Biological Elicitors of Plant Secondary Metabolites: Mode of Action and Use in the Production of NutraceuticsSimone FerrariAbstractIntroductionBiological Elicitors of Defence Responses in PlantsPerception and Transduction of General ElicitorsEmerging Techniques to Improve