This book discusses the mechanisms leading to immune-mediated tissue rejection. It follows the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple.
This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).
Part One - From “delayed allergy reaction” to the “immunologic constant or rejection” 1. Ena Wang and Francesco M Marincola Part Two - The immune biology of rejection; basic principles 2. Experimental models of rejection – Anil Shanker A 3. Cancer and Inflammation – Alberto Mantovani 4. The immunologic switch – Giorgio Trinchieri 5. The angiogenic switch – Douglas Noonan 6. Chemokines and cytotoxic effector molecules in rejection – Alan Krensky 7. Immune cell activation: the clinical perspective – David F Stroncek Part Three - Circulating patterns associated with chronic and acute immune pathology 8. Immune signatures detectable in peripheral lymphocytes: a modular view – Damien Chaussabel 9. Immune signatures associated with unresolving compared to resolving infections: the HCV model – Robert E Lanford 10. Immune signatures associated with unresolving infections: the HIV model – Luigi Buonaguro 11. Immune signatures associated with the cancer-bearing status – Peter P Lee Part Four - Tissue-specific patterns associated with chronic inflammatory processes 12. Signatures associated with destructive autoimmune pathologies – Steve Jacobson 13. Predictors of favorable outcome in cancer – Zoltan Pos 14. Other predictors of outcome - George Coukos 15. Transcriptional profiling of melanoma as a potential predictive biomarker for response to immunotherapy – Thomas F. Gajewski 16. Predictors of allograft rejection - Sarwal Minnie Part Five - Signatures associated with acute rejection 17. Graft vs Host – Fran Hakim 18. Tumor rejection– Ena Wang 19. Allograft rejection – Davide Bedognetti