Molecular Defects in Cardiovascular Disease

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca²⁺ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end.

A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

A. Molecular Mechanisms in Heart Disease

1. Calcium overloading-induced oxidative stress-mediated cellular and subcellular remodeling

Y. Cheema, A.U. Shahbaz, S.K. Bhattacharya, R.A. Ahokas, Y.Sun, I.C. Gerling and K.T. Weber

2. Intracellular MMP-2: Role in normal and diseased hearts

N. Youssef and R. Schulz

3. Control of the mesenchymal-derived cell phenotype by Ski and Meox2: A putative mechanism for post-developmental phenoconversion

R.H. Cunnington, J.T. Wigle, J.M. Douville, D.H. Freed, D. Schaafsma, S. O'Connor, S. Gupta, S.G. Rattan, A. Halayko and I.M.C. Dixon

4. Elevated Na⁺/H⁺ exchanger expression and its role in myocardial disease

L. Fliegel

5. Impact of perinatal chronic hypoxia on cardiac tolerance to acute ischemia

B. Ostadal, I. Ostadalova, F. Kolar, I. Netuka, O. Szarszoi,

6. Stem cell, microRNA and redox cycling

P. Mukhopadhay, N. Gurusamy and D.K. Das

7. Cardiac cell therapy: Present and future

D.K. Singla

B. Cardiac Hypertophy and Heart Failure

8. Macroscopic and microscopic aspects of cardiac dysfunction in congestive heart failure

H.E.D.J. ter Keurs

9. Cardiac dysfunction and metabolism: Unravelling the molecular cross-talk

V. Sharma and J.H. McNeill

10. Metabolic remodeling of the hypertrophied heart

J.M. Dai and M.F. Allard

11. Mechanisms for the regulation of phospholipase C gene expression in cardiac hypertrophy

P.S. Tappia

12. Molecular changes in fatty acid oxidation in the failing heart

J.S. Jaswal, W. Keung, W. Wang, J.R. Ussher and G.D. Lopaschuk

13. Cardiolipin metabolism in experimental and human heart failure

G.M. Hatch

14. Mechanisms underlying development of cardiomyocyte hypertrophy via Na-H exchange stimulation

M. Karmazyn

15. The structural basis of cardiac dysfunction in human heart failure

S. Hein, S. Kostin and J. Schaper

16. Hormonal mechanisms of cardiac remodeling in heart failure

A.P. Babick, V. Elimban and N.S. Dhalla

17. Modulators of remodeling after myocardial infarction

B.I. Jugdutt

18. Phosphodiesterase-5 inhibitors in protection against doxorubicin-induced cardiomyopathy

S. Koka and R.C. Kukreja

C. Hypertension and Diabetes

19. Molecular basis of pulmonary hypertension in left heart failure

B. Raj, H.S. Pillai and C.C. Kartha

20. Modulation of G_i protein expression in hypertension: Molecular mechanisms

M.B. Anand-Srivastava

21. Vascular dysfunction in heart disease

R. Perrault and P. Zahradka

22. Cellular and molecular mechanisms associated with salicylate inhibition of intimal hyperplasia balloon catheter-induced vascular injury

S.N. Murthy, P.J. Kadowitz and D.B. McNamara

23. Involvement of growth factor receptor and non receptor protein tyrosine kinases in endothelin 1 and angiotensin II-induced signaling pathways in the cardiovascular system.

G. Vardatsikos and A.K. Srivastava

24. Sarco/endoplasmic reticulum Ca²⁺ pump damage by oxidative stress: Implications for Ca²⁺ entry

G. Akolkar and A.K. Grover

25. Obesity-hypertension: Leptin as the common link to cardiovascular and renal dysregulation

S. Kshatriya, H. Kozman, D. Siddiqui, L. Bhatta, K. Liu, A. Salah, T. Ford, R. Michiel, R. Carhart and D. Villarreal

26. Cardiorenal protection in diabetes mellitus

H. Vashistha, L.G. Meggs and A. Malhotra

27. Molecular mechanisms in the pathogenesis of diabetic cardiomyopathy

S. Chakrabarti