Memory T Cells

Maurizio Zanetti, MD, is a Professor of Medicine at the University of California, San Diego (UCSD), and member of the Moores UCSD Cancer Center. He is the Director of the Immunology laboratory at the Moores UCSD Cancer Center as well as of the Graduate Course in Immunology at UCSD. Main interests include the generation and maintenance of memory T cells with protective valueagainst disease. These responses are studied with respect to cancer and influenza virus infection. His work in humans is devoted to to the immunology of telomerase reverse transcriptase, a prototype universal cancer antigen. He served in the program Committee of the American Society of Immunology, and as Associate Editor for the Journal of Immunology and Cellular Immunology. He is a member of the AmericanAssociation of Immunologists and American Society for Clinical Investigation. He received his MD from the University of Padova, Italy.Stephen P. Schoenberger, PhD, is a member in the Laboratory of CellularImmunology at the La Jolla Institute for Allergy and Immunology and adjunct faculty in the division of Hematology and Oncology at the University of California at San Diego School of Medicine. His main research interests include CD8+ T-cell immunememory and antigen presentation cell function. He is a member of the editorial advisory board of Journal of Experimental Medicine, and Associate Editor at the Journal of Immunology, and is a member of numerous national and international scientific organizations including the Dutch Immunology Society, The AmericanAssociation of Immunologists. He received his PhD from the University of California in Los Angeles, USA.

Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.

Discusses the role of Schnurri-2, which plays a critical role in cell growth, signal transduction and lymphocyte development, in the generation of memory CD4 T cells

Memory Th1/Th2 Cell Generation Controlled by Schnurri-2.- Transcriptional Regulation during CD8 T-Cell Immune Responses.- The Role of Interleukin-2 in Memory CD8 Cell Differentiation.- The Role of Inflammation in the Generation and Maintenance of Memory T Cells.- The Role of OX40 (CD134) in T-Cell Memory Generation.- The Role of Precursor Frequency in the Differentiation of Memory T Cells: Memory by Numbers.- CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections.- Longevity of T-Cell Memory following Acute Viral Infection.- Principles of Memory CD8 T-Cells Generation in Relation to Protective Immunity.- Memory T Cells in Rhesus Macaques.- Memory T-Cell Subsets in Parasitic Infections.- Antigen Specific Memory T Cells and Their Putative Need for the Generation of Sustained Anti-Tumor Responses.- Memory T-Cell Responses and Survival in Human Cancer: Remember to Stay Alive.- Analysis of Vaccine-Induced T Cells in Humans with Cancer.- Memory T-Cell Homeostasis and Senescence during Aging.