Tissue and Organ Regeneration in Adults

Tissue engineering is the first discipline of bioengineering which explicitly integrates molecular biology with physics and chemistry. It emphasizes research in the synthesis of new tissues and organs in vivo and in vitro. The treatment is uniform and deliberately directed toward the different backgrounds of students from the physical and life sciences. The book also features an extensive bibliography, and extensive bodies of independent data on organ regeneration from the journal literature. In short, the generic organ-blind methodology described in this volume should be useful to most students and practitioners of tissue engineering. The emphasis throughout this volume is on the systematic development of the viewpoint that regeneration is an instance of synthesis of tissues and organs. This has three simple consequences. The first is the requirement for a special kind of experimental reactor, free of tissues that do not regenerate spontaneously. The second calls for meticulous physicochemical and biological characterization of the end products from such a synthetic reaction. The third calls for the required use of appropriate non-diffusible regulators in the experimental reactor. These insoluble matrices induce adult cells to abandon their normal proclivity in closing up adult wounds in exchange for synthesizing physiological tissues. This approach is independent of the organ under study. It is developed in substantial depth during the first several chapters by limiting the discussion to just two two organs that are quite different from each other, namely skin and peripheral nerves. The conclusions from this analysis apply to either organ with roughly equal strength. This intriguing result clearly suggests a generic methodology for synthesis of other organs.
The book also features an extensive bibliography, and extensive bodies of independent data on organ regeneration from the journal literature have been collected together for the first time and accessibly presented in tabular form, enabling direct comparisons. In short, the generic organ-blind methodology described in this volume should be useful to most students and practitioners of tissue engineering.

Tissue engineering is the first discipline of bioengineering which explicitly integrates molecular biology with physics and chemistry. It emphasizes research in synthesis of new tissues and organs in vivo and in vitro, Using data and analyses obtained from the study of skin and peripheral nerves the author makes the case that what shows promise with these two organs suggests a generic methodology for synthesis of other organs. The treatment is uniform and deliberately directed toward the different backgrounds of students from the physical and life sciences.

Preface. 1. The Irreversibility of Injury. 2. Nonregenerative Tissues. 3. Anatomically Well-Defined Defects. 4. The Defect Closure Rule. 5. Regeneration of Skin. 6. Regeneration of a Peripheral Nerve. 7. Irreducible Processes for Synthesis of Skin and Peripheral Nerves. 8. The Antagonistic Relation Between Contraction and Regeneration. 9. Kinetics and Mechanism I. Spontaneous Healing. 10. Kinetics and Mechanism II. Induced Regeneration. Appendix A. Method of estimation of critical axon elongation of an arbitrary tubulated device bridging two nerve stumps. Index.