Fertility Preservation

A growing majority of women in the western hemisphere have been delaying initiation of childbearing to later in life. In this book, the editors provide up-to-date strategies for fertility preservation in women and men who require gonadotoxic treatment.

A growing majority of women in the western hemisphere have been delaying initiation of childbearing to later in life. Consequently, more women in their late 30s to early 40s are attempting to get pregnant for the first time than ever before. Since the incidence of most cancers increases with age, delayed childbearing results in more female cancer survivors interested in fertility preservation.

In this book, the editors provide strategies for fertility preservation in women and men who require gonadotoxic treatment. In addition, epidemiologic, ethical, medico-legal, psychologic, and social aspects of fertility preservation are discussed. Using a format that combines concise scientific background with practical methodological information and easy-to-grasp algorithms, the chapters all conform to a uniform structure, including a brief abstract, keyword glossary, step by step protocol of laboratory procedures, key issues in commentary and a list of references. The result is a unique, practical reference guide for reproductive endocrinologists, urologists, embryologists, reproductive scientists, and oncologists.

Foreword

Preface

Contributors
I. Overview of Fertility Preservation: Epidemiologic, Social, Ethical, and Medicolegal Aspects

1. The Epidemiology of Fertility Preservation
William Murk and Emre Seli

2. Ethical Discussions in Approaching Fertility Preservation
Pasquale Patrizio

II. Fertility Preservation in Women

3. Ovarian Follicle Development and Fertility Preservation
Yuichi Niikura and Joshua Johnson

4. Impact of Chemotherapy and Radiotherapy on the Ovary
Maya L. Kriseman and Ertug Kovanci

5. Impact of Chemotherapy and Radiotherapy on the Uterus
Abbie L. Fields, Deleep Kumar Gudipudi, and Giuseppe Del Priore

6.  Ovarian Transposition
Elena S. Ratner, Dan-Arin Silasi, and Masoud Azodi

7. Embryo Cryopreservation and Alternative Controlled Ovarian Hyperstimulation Strategies for Fertility Preservation
Bulent Urman, Ozgur Oktem, and Basak Balaban

8. Oocyte Cryopreservation
Andrea Borini and Veronica Bianchi

9. Ovarian Tissue Cryopreservation and Autotransplantation
Mohamed A. Bedaiwy, Gihan M. Bareh, Katherine J. Rodewald, and William W. Hurd

10. Oocyte In Vitro Maturation: Formidable Obstacles on the Road to Fertility Preservation
David F. Albertini

11. Whole Ovary Cryopreservation
Hulusi Bulent Zeyneloglu, Gogsen Onalan, and Cengiz Karakaya

12. Risk of Transplanting Cryopreserved Ovarian Tissue in Women with Malignancies
Javier Domingo del Pozo, M. Sánchez-Serrano, and Antonio Pellicer Martinez

13. Gonadotropin Releasing Hormone Agonists in Fertility Preservation
Hakan Cakmak and Emre Seli

14. Fertility Preservation in Gynecologic Malignancies
Christine E. Richter and Peter E. Schwartz

15. Third-Party Reproduction and Adoption After Cancer: Practical and Emotional Considerations
Dorothy A. Greenfeld

16. Pregnancy and Cancer Treatment
Christine Laky and Mert Ozan Bahtiyar

17. Fertility Preservation Strategies in Healthy Women
Enrique Soto and Alan B. Copperman

18. Approach to Fertility Preservation in Adult and Pre-pubertal Females
Kenny A. Rodriguez-Wallberg and Kutluk Oktay

III. Fertility Preservation in Men

19. Spermatogenesis and Testicular Function
Ciler Celik-Ozenci

20. Impact of Radiotherapy and Chemotherapy on the Testis
Carolina Ortega and Herman Tournaye

21. Impact of Paternal Exposure to Gonadotoxins on Embryo and
 Offspring and the Male Evaluation
Kathleen Hwang,  Paul Gittens,  Desiderio Avila Jr.,  and Larry I. Lipshultz

22. Update on Sperm Banking
Pankaj Talwar

23. Preservation of Sperm Isolates or Testicular Biopsy Samples
Bhushan K. Gangrade

24. Germ Cell Transplantation and Neospermatogenesis
Queenie V. Neri, Zev Rosenwaks, and Gianpiero D. Palermo

25. Testicular Tissue Transplantation for Fertility Preservation
Jose R Rodriguez-Sosa, Stefan Schlatt, and Ina Dobrinski

26. Stem Cells and Fertility Preservation in Males
Marcia Riboldi, Ana Isabel Marqués Marí, and Carlos Simón

27. Approach to Fertility Preservation in Adult and Pre-pubertal Males
Fnu Deepinder and Ashok Agarwal

IV. Protocols

28. Embryo Cryopreservation and Alternative Strategies for Controlled Ovarian Hyperstimulation
Bulent Urman, Ozgur Oktem, and Basak Balaban

29. Oocyte Cryopreservation
Andrea Borini and Veronica Bianchi

30. Ovarian Tissue Cryopreservation
Mohamed A Bedaiwy, Gihan M Bareh, Katherine J. Rodewald, William W. Hurd, and Ashok Agarwal

31. Sperm Preparation and Freezing for Banking
Pankaj Talwar

32. Preservation of Sperm Isolates and Testicular Biopsy Samples for Banking
Bhushan K. Gangrade

33. Testis Tissue Xenografting
Jose R Rodriguez-Sosa, Stefan Schlatt, and Ina Dobrinski

Index