Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with.
HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.
Preface
Chapter 1 - The HIV Epidemic in the United States - Current Trends, 2010
John T. Brooks and Mi Chen
Chapter 2 - Epidemiology of Liver Disease in Human Immunodeficiency Virus Infected Persons
Adeel A. Butt
Chapter 3 - Current and Future Treatment Guidelines for HIV
Judith Feinberg
Chapter 4 - Pathology of HIV-Associated Liver Disease
Amy E. Noffsinger and Jiang Wang
Chapter 5 - Non-invasive Markers of Liver Injury and Fibrosis
Jenny O. Smith and Richard K. Sterling
Chapter 6 - Mechanisms of Alcoholic Steatosis/Steatohepatitis
Zhanxiang Zhou, Ross E. Jones, and Craig J. McClain
Chapter 7 - Immunopathogenesis of Liver Injury
Mohamed Tarek M. Shata
Chapter 8 - Host Gene Polymorphisms and Disease/Treatment Outcomes in HIV and Viral Co-infections
Jacob K. Natterman and Jurgen Rockstroh
Chapter 9 - Effects of HIV on Liver Cell Populations
Meena B. Bansal and Jason T. Blackard
Chapter 10 - HIV Replication
Vladimir A. Novitsky and Max Essex
Chapter 11 - Hepatitis C - Natural History
Mark S. Sulkowski
Chapter 12 - Natural History of Hepatitis B Virus in HIV-Infected Patients
Chloe L. Thio
Chapter 13 - Other Hepatitis Viruses and HIV Infection
José V. Fernández-Montero and Vincent Soriano
Chapter 14 - Hepatitis B Virus: Replication, Mutation and Evolution
Amy C. Sherman and Shyam Kottilil
Chapter 15 - Hepatitis C Virus Treatment in HIV
Raymond Chung and Gyanprakash Avinash Ketwaroo
Chapter 16 - Treatment of Hepatitis B in HIV-Infected Persons
Ellen Kitchell and Mamta K. Jain
Chapter 17 - Prevention of Hepatitis Infection in HIV-Infected Patients
Edgar Turner Overton and Judith A. Aberg
Chapter 18 - Alanine Aminotransferase (ART) Hepatotoxicity
Norah J. Shire
Chapter 19 - Management of End Stage Liver Disease and the Role of Liver Transplantation in HIV infected Patients
Marion G. Peters and Peter G. Stock
Chapter 20 - Assessment and Treatment of Alcohol and Substance Use Disorders in Patients with HIV Infection
Ashley D. Bone and Andrew F. Angelino
Chapter 21 - Racial Disparities in HIV and Liver Disease
Nyingi M. Kemmer
Chapter 22 - Quality of Life Issues in Patients with HIV and Liver Disease
Cindy L. Bryce and Joel Tsevat