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Autor: Peter D. Adams
ISBN-13: 9781441910752
Einband: eBook
Seiten: 272
Sprache: Englisch
eBook Typ: PDF
eBook Format: eBook
Kopierschutz: Adobe DRM [Hard-DRM]
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Cellular Senescence and Tumor Suppression

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As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.
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This book covers the latest findings in the link between cellular senescence and cancer including telemores and senescence signals, the senescent phenotype, and the physiological effects of senescence, including therapeutic applications.
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As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.
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Introduction: J Sedivy. Section 1. Senescence signals. 1. Telomere biology and biochemistry: 1, J Karlseder; 2, T de Lange; 3, L Harrington. 2. Short telomere-driven senescence: 1, F d'Adda di Fagagna; 2, N Sharpless; 3, V Bohr. 3. Oncogene-induced senescence: 1, M Serrano; 2, J Bartek; 3, G, Ferbeyre. 4. Stress-induced senescence: 1, T Finkel; 2, V Gorbunova; 3, E Hara; 4, F Ishikawa. 5. Modulation of senescence by extracellular growth factors: 1, P Adams. Section 2. The senescent phenotype. 6. The senescent phenotype and its evolution: 1, J Campisi. 7. Chromatin structure in senescent cells: 1, E Medrano; 2. M Narita. 8. A comparison of senescence in mouse and human cells: 1, C Greider; 2, M Blasco. Section 3. The physiological consequences of senescence. 9. Tumor suppression: 1, G Peters; 2, N Sharpless; 3, S Chang. 10. Tissue aging: 1, L Rudolph; 2, A Trumpp. 11. Senescence as a potential therapeutic tool: 1, C Schmitt; 2, S Lowe.

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Autor: Peter D. Adams
ISBN-13 :: 9781441910752
ISBN: 1441910751
Verlag: Springer New York
Seiten: 272
Sprache: Englisch
Auflage 2010
Sonstiges: Ebook