Cardiovascular Genetics and Genomics for the Cardiologist

Victor J. Dzau, MD James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA Choong-Chin Liew, PhD Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine.

Contributors. Foreword. Introduction. 1 The gene in the twenty-first century. Choong-Chin Liew, Victor J. Dzau. Part I: Cardiovascular single gene disorders. 2 Monogenic hypercholesterolemia. Ruth McPherson. 3 Hypertrophic cardiomyopathy. Ali J. Marian. 4 Dilated cardiomyopathy and other cardiomyopathies. Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus. 5 The long QT syndrome. Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima. Part II: Cardiovascular polygenic disorders. 6 Atherosclerosis. Paivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew. 7 Heart failure. Markus Meyer, Peter VanBuren. 8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension. Kiat Tsong Tan, Choong-Chin Liew. Part III: Therapies and applications. 9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects. Ion S. Jovin, Frank J. Giordano. 10 Stem cell therapy for cardiovascular disease. Emerson C. Perin, Guilherme V. Silva. 11 Pharmacogenetics and personalized medicine. Julie A. Johnson, Issam Zineh. 12 The potential of blood-based gene profiling for disease assessment. Steve Mohr, Choong-Chin Liew. Index. Colour plates