The Role of Nitric Oxide in Heart Failure

Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure

Foreword. Preface. Acknowledgements. Part I: NO and Pathophysiology of Heart Failure. Nitric Oxide in Heart Failure: Friend or Foe; B.I. Jugdutt. NO and the Vasculature: Where Does It Come from and What Does It Do? K.L. Andrews, C.R. Triggle, A. Ellis. Myocardial Contractile Effects of Nitric Oxide Walter; J. Paulus, J.G.F. Bronzwaer. Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies; D. Alonso, M.W. Radomski. Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction; T.J. Anderson. Regulation of Cardiac Remodeling by Nitric Oxide: Focus on Cardiac Myocyte Hypertrophy and Apoptosis; K.C. Wollert, H. Drexler. Role of Nitric Oxide in the Pathophysiology of Heart Failure; H.C. Champion, M.W. Skaf, J.M. Hare. Nitric Oxide, Cell Death, and Heart Failure; J.-i. Oyama, S. Frantz, C. Blais, R.A. Kelly, T. Bourcier. Acute and Chronic Endothelial Dysfunction: Implications for the Development of Heart Failure; A. Linke, F. Recchia, Xiaoping Zhang, T.H. Hintze. The Role of NOS in Heart Failure: Lessons from Murine Genetic Models; I.N. Mungrue, M. Husain, D.J. Stewart. Part II: NO and Cardiovascular Therapeutics. Nitric Oxide and Cardiovascular Protection; B.I. Jugdutt. Angiotensin II and Nitric Oxide Interaction; M. de Gasparo. The Nitric Oxide-Endothelin-1 Connection; D. Alonso, M.W. Radomski. The Therapeutic Effect of Natriuretic Peptides in Heart Failure; Differential Regulation of Endothelial and Inducible Nitric Oxide Synthases; A. Calderone. Mechanisms Underlying Nitrate-Induced Endothelial Dysfunction: Insight from Experimental and Clinical Studies; A. Warnholtz, N. Tsilimingas, M. Wendt, T.H. Hintze. Statins and the Role of Nitric Oxide in Chronic Heart Failure; S. von Haehling, S.D. Ankel, E. Bassenge. Role of Nitric Oxide in Matrix Remodeling in Diabetes and Heart Failure; S.C. Yagi, M.R. Hayden. Peroxynitrite in Myocardial Ischemia-Reperfusion Injury; M.M. Lalu, Wenjie Wang, R. Schulz. The Role of the NO Axis and its Therapeutic Implications in Pulmonary Arterial Hypertension; E.D. Michelakis. Nitric Oxide and Cardioprotection During Ischemia-Reperfusion; B.I. Jugdutt. Index.