Inflammatory Bowel Disease: From Bench to Bedside

This book is intended to be more than a comprehensive compilation of reviews by individual authors on different aspects of inflammatory bowel diseases. It is intended that the individual chapters be components of a coherent, albeit detailed, story of the local and systemic pathophysiology of intestinal inflammation, with a well-reasoned series of management strategies. Our goal was not only to produce a standard reference text, but also to present research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders. Our vision was to have a book that would blend recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease. It is our hope that the book will illustrate the effectiveness of a team approach of basic scientists and clinician investigators in this field. The book will give the reader a glimpse of where the field is moving and an idea of likely research directions in the future. Of course, it is our personal wish that this book will stimulate ideas for future research.

Preface. Section 1: The Laboratory Bench. 1. Introduction: Inflammatory Bowel Diseases: From Bench to Bedside; F. Shanahan, et al. 2. The Changing Faces of Crohn's Disease and Ulcerative Colitis; A. Ekbom. 3. Genetics of Inflammatory Bowel Disease; K.D. Taylor, J.I. Rotter, H. Yang. 4. Experimental Mouse Models of Inflammatory Bowel Disease: New Insights Into Pathogenic Mechanisms; C.O. Elson, C. T. Weaver. 5. The Normal Intestinal Mucosa - A State of `Controlled Inflammation'; C. Fiochi. 6. The Lymphocyte-Epithelial-Bacterial Interface; R. Hershberg, R. Blumberg. 7. The Mucosal Inflammatory Response. Cytokines and Chemokines; F. Cominelli, K. O. Arseneau, T. T. Pizarro ; 8. Role of the Microcirculation in Chronic Gut Inflammation; M. B. Grisham, F. S. Laroux, D. N. Granger. 9. Remission, Relapse, Intestinal Healing and Repair; M. N. Göke , D. Podolsky. 10. Antibodies in the Exploration of Inflammatory Bowel Disease Pathogenesis and Disease Stratification; J. Braun, O. Cohavy, M. Eggena. 11. Pathophysiology of Inflammatory Bowel Disease: The Effect of Inflammation on Intestinal Function ; S. M. Collins, K. Croitoru. 12. Systemic Consequences of Intestinal Inflammation; K. A. Papadakis , M.T. Abreu. Section II: The Bedside. 13. Understanding Symptoms and Signs in Inflammatory Bowel Disease; C. C. Cronin, F. Shanahan 14. Clinical Course and Complications of Ulcerative Colitis and Ulcerative Proctitis; R. Panaccione, L. R. Sutherland. 15. Clinical Features and Complications of Crohn's Disease; W. J. Tremaine. 16. Mechanisms of Systemic Inflammation Associated With Intestinal Injury; R. B. Sartor. S. N. Lichtman 17. Pathology of Inflammatory Bowel Diseases: A Critical Appraisal in Diagnosis and Management; G. Cortina, K. Lewin. 18. An Endoscopic and Histologic Perspective of Diagnosis: When, Where and What to Do; C. N. Bernstein, R. H. Riddell. 19. Radiologic (Radiographic) and Imaging Features of Ulcerative Colitis and Crohn's Disease; E. Fitzgerald. 20. New Diagnostic Approaches; L. Kam, E. Vasiliauskas. 21. Differential Diagnosis of Colitis; S. C. Eng, C. M. Surawicz. 22. 'Disease Management' in Chronic Medical Conditions; D. H. Alpers. 23. Pharmacoeconomic and Inflammatory Bowel Disease; B. G. Feagan. 24. Measuring Quality of Life in Inflammatory Bowel Disease; E.J. Irvine. 25 Additional Chapters. Section III: Back to the Laboratory Bench. 50. Epilogue: Bench to Bedside and Back to Bench; S.R. Targan, L. C. Karp, F. Shanahan. Index.