Solid State Characterization of Pharmaceuticals

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection

The field of solid state characterization is central to thepharmaceutical industry, as drug products are, in an overwhelmingnumber of cases, produced as solid materials. Selection of theoptimum solid form is a critical aspect of the development ofpharmaceutical compounds, due to their ability to exist in morethan one form or crystal structure (polymorphism). These polymorphsexhibit different physical properties which can affect theirbiopharmaceutical properties.This book provides an up-to-date review of the currenttechniques used to characterize pharmaceutical solids. Ensuringbalanced, practical coverage with industrial relevance, it covers arange of key applications in the field.The following topics are included:* Physical properties and processes* Thermodynamics* Intellectual guidance* X-ray diffraction* Spectroscopy Microscopy* Particle sizing* Mechanical properties* Vapour sorption* Thermal analysis & Calorimetry* Polymorph prediction* Form selection

1. Introduction to the Solid State - Physical Properties and Processes - Ingvar Ym´en2. X-Ray Diffraction - C. J. Gilmore3. Spectroscopic Characterization - Andrew O'Neil and Howell Edwards4. Thermal Analysis - Conventional Techniques - Mark Saunders and Paul Gabbott5. Thermal Analysis - Dielectric Techniques - Susan Barker and Milan D. Antonijevic6. Isothermal Calorimetric Analysis - Andrew Hills7. Calorimetric Methods - Solution Calorimetry - Simon Gaisford8. Vapour Sorption and Surface Analysis - Jerry Y. Y. Heng and Daryl R. Williams9. Microscopy - Gary Nichols10. Particulate Analysis - Mechanical Properties - R. J. Roberts11. Particulate Analysis - Particle Size - Xian-Ming Zeng12. Computational Polymorph Prediction - Sarah L. Price and Louise S. Price13. Patenting of Inventions Relating to Polymorphs - Bertrand Gellie, Claire Johnson and Thomas Weisbrod14. A 'Roadmap' to Solid Form Selection - Richard Storey