Understanding Medical Research

Medical students and junior and senior doctors are frequently called upon to give research presentations, write reports, and answer exam questions on specific areas of medical research. Understanding Medical Research: The Studies That Shaped Medicine is an exciting new title that offers a unique and valuable approach to understanding historically influential studies in important areas of medicine. Featuring chapters from Sir Liam Donaldson and Sir David Weatherall, amongst others, world leading researchers identify ten primary research papers that have shaped the direction of research in their given topic, examining why they were carried out, key findings, and how they changed the field. Each chapter also contains short sections on Key Questions Remaining which outline outstanding areas where further research is needed, and a link to Key Laboratories/Clinics which point the reader to major research groups of international standing. Covering the seminal research in core areas of medicine, Understanding Medical Research provides an authoritative framework on each topic for medical students and healthcare professionals.

Medical students and junior and senior doctors are frequentlycalled upon to give research presentations, write reports, andanswer exam questions on specific areas of medical research.Understanding Medical Research: The Studies That ShapedMedicine is an exciting new title that offers a unique andvaluable approach to understanding historically influential studiesin important areas of medicine.Featuring chapters from Sir Liam Donaldson and Sir DavidWeatherall, amongst others, world leading researchers identify tenprimary research papers that have shaped the direction of researchin their given topic, examining why they were carried out, keyfindings, and how they changed the field.Each chapter also contains short sections on 'KeyQuestions Remaining' which outline outstanding areas wherefurther research is needed, and a link to 'KeyLaboratories/Clinics' which point the reader to majorresearch groups of international standing.Covering the seminal research in core areas of medicineUnderstanding Medical Research provides an authoritativeframework on each topic for medical students and healthcareprofessionals.

Contributors, ixPreface, xivForeword, xvSir Liam DonaldsonAcknowledgements, xviChapter 1 Population Health, 1Douglas Noble, Felix Greaves and Sir Liam DonaldsonChapter 2 Patient Safety, 14Felix Greaves, Douglas Noble and Sir Liam DonaldsonChapter 3 Heart Failure, 24Martin R. Cowie and Kaushik GuhaChapter 4 Acute Coronary Syndrome (NSTEMI), 34Wei Yao Lim and Colin BerryChapter 5 Lipids, Dyslipidaemia and Cardiovascular Disease, 46Gilbert R. ThompsonChapter 6 Atrial Fibrillation, 58Kunihiro Nishida and Stanley NattelChapter 7 Asthma, 69Tak H. Lee and Leonard SiewChapter 8 Cystic Fibrosis, 81Andrew BushChapter 9 Chronic Obstructive Pulmonary Disease, 92Paul A. Ford and Peter J. BarnesChapter 10 Pneumonia, 103John M. Wrightson, Eleanor K. Mishra and Robert J.O. DaviesChapter 11 Stroke, 115Philip M.W. Bath and Nikola SpriggChapter 12 Parkinson's Disease, 127Edward J. Newman and Donald G. GrossetChapter 13 Epilepsy, 138Fergus J. Rugg-GunnChapter 14 Motor Neuron Disease, 151Martin R. Turner and Kevin TalbotChapter 15 Migraine, 162Mark W. WeatherallChapter 16 Multiple Sclerosis, 171Alasdair Coles and Alastair CompstonChapter 17 The Autoimmune Basis for Guillain-Barr_e Syndrome, 183John A. Goodfellow and Hugh J. WillisonChapter 18 Helicobacter pylori, Peptic Ulcers and Gastric Cancer, 193Anahita Dua and Emad M. El-OmarChapter 19 Acute Liver Failure, 204James O'Beirne and Andrew K. BurroughsChapter 20 Haemostasis and Thrombosis, 216Charles Percy and Raza AlikhanChapter 21 The Inherited Disorders of Haemoglobin, 224Sir David WeatherallChapter 22 Diabetes Therapy and the Prevention of Vascular Damage, 235Philip HomeChapter 23 Rheumatoid Arthritis, 246Jonathan C.W. Edwards and Maria J. LeandroChapter 24 Osteoarthritis, 254Kirsten White, Alexander S. Nicholls, Anushka Soni and Nigel ArdenChapter 25 Systemic Vasculitis, 263Joanna Robson, Ravi Suppiah and Raashid LuqmaniChapter 26 Polycystic Kidney Disease, 275Qi QianChapter 27 Glomerular Disease and the Nephrotic Syndrome, 285Jenny Papakrivopoulou and Robert UnwinChapter 28 Acquired Immunodeficiency Syndrome, 296Tica Pichulik and Alison SimmonsChapter 29 Transplantation, 309Elizabeth SimpsonChapter 30 Autoimmunity, 320Jonathan C.W. Edwards and Geraldine CambridgeChapter 31 The Biochemistry of Depression, 329Philip J. CowenChapter 32 Schizophrenia and the Dopamine Hypothesis, 338Mandy Johnstone and Eve C. JohnstoneChapter 33 Alzheimer's Disease, 349Gordon Wilcock and Alistair BurnsIndex, 361