Clinical Biochemistry

Clinical Biochemistry Lecture Notes presents the fundamental science behind common biochemical investigations used in clinical practice. Taking a system-based approach, it explores the underlying physiological rationale for tests, with each test explained within the context of disruption by disease. It also explores the value and limitations of biochemical investigations, while helping readers to quickly develop the knowledge and skills required to select the appropriate investigations for diagnosis and management, and to correctly interpret test results. Case studies throughout chapters place the information within a clinical context to further assist readers in the development of test-selection and interpretation skills. Key features include: A comprehensive, yet concise overview of the science behind common biochemical investigations Helps readers rapidly acquire a fully integrated, practical understanding of biochemical diagnostics Full-colour flowcharts and algorithms detailing the rationale for tests, the biochemical processes involved, and test procedures, for quick comprehension and reference More clinical cases demonstrating application to practice Now in its tenth edition, this classic introductory, reference, and revision text is indispensable to medical students, and all those who want to quickly acquire a practical understanding of the scientific principles underpinning biochemical tests and a working knowledge of test selection, test procedures, and the interpretation of results within a clinical context.

Clinical Biochemistry Lecture Notes presents the fundamental science behind common biochemical investigations used in clinical practice. Taking a system-based approach, it explores the underlying physiological rationale for tests, with each test explained within the context of disruption by disease. It also explores the value and limitations of biochemical investigations, while helping readers to quickly develop the knowledge and skills required to select the appropriate investigations for diagnosis and management, and to correctly interpret test results. Case studies throughout chapters place the information within a clinical context to further assist readers in the development of test-selection and interpretation skills.Key features include:* A comprehensive, yet concise overview of the science behind common biochemical investigations* Helps readers rapidly acquire a fully integrated, practical understanding of biochemical diagnostics* Full-colour flowcharts and algorithms detailing the rationale for tests, the biochemical processes involved, and test procedures, for quick comprehension and reference* More clinical cases demonstrating application to practiceNow in its tenth edition, this classic introductory, reference, and revision text is indispensable to medical students, and all those who want to quickly acquire a practical understanding of the scientific principles underpinning biochemical tests and a working knowledge of test selection, test procedures, and the interpretation of results within a clinical context.

Preface viList of abbreviations viiAbout the companion website x1 Requesting and interpreting tests 12 Disturbances of water, sodium and potassium balance 123 Acid-base balance and oxygen transport 304 Renal disease 435 Disorders of calcium, phosphate and magnesium metabolism 606 Diabetes mellitus and hypoglycaemia 777 Disorders of the hypothalamus and pituitary 918 Abnormalities of thyroid function 1059 Disorders of the adrenal cortex and medulla 12110 Investigation of gonadal function infertility, menstrual irregularities and hirsutism 13911 Pregnancy and antenatal screening 15812 Cardiovascular disorders 16713 Liver disease 18314 Gastrointestinal tract disease 19815 Nutrition 20816 Inflammation, immunity and paraproteinaemia 22417 Malignancy and tumour markers 23418 Disorders of iron and porphyrin metabolism 24119 Uric acid, gout and purine metabolism 25220 Central nervous system and cerebrospinal fluid 25921 Therapeutic drug monitoring and chemical toxicology 26322 Clinical biochemistry in paediatrics and the elderly 276Index 295