Molecular Neuroendocrinology

Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems.The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today's neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes.* Written by a team of internationally renowned researchers* Both print and enhanced e-book versions are available* Illustrated in full colour throughoutThis is the third volume in a new Series 'Masterclass in Neuroendocrinology' , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

List of Contributors, viiSeries Preface, xiAbout the Companion Website, xiiiIntroduction 1David Murphy and Harold GainerPart A Genome and Genome Expression1 Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System 5Zita Liutkevici^u¯te and Christian W. Gruber2 The Neuroendocrine Genome: Neuropeptides and Related Signaling Peptides 25J. Peter H. Burbach3 Transcriptome Dynamics 57David A. Carter, Steven L. Coon, Yoav Gothilf , Charles K. Hwang, Leming Shi, P. Michael Iuvone, Stephen Hartley, James C. Mullikin, Peter Munson, Cong Fu, Samuel J. Clokie, and David C. Klein4 New Players in the Neuroendocrine System: A Journey Through the Non-coding RNA World 75Yongping Wang, Edward A. Mead, Austin P. Thekkumthala, and Andrzej Z. Pietrzykowski5 Transcription Factors Regulating Neuroendocrine Development, Function, and Oncogenesis 97Judy M. Coulson and Matthew Concannon6 Epigenetics 121Chris MurgatroydPart B Proteins, Posttranslational Mechanisms, and Receptors7 Proteome and Peptidome Dynamics 141Lloyd D. Fricker8 Neuropeptidomics: The Characterization of Neuropeptides and Hormones in the Nervous and Neuroendocrine Systems 155Ning Yang, Samuel J. Irving, Elena V. Romanova, Jennifer W. Mitchell, Martha U. Gillette, and Jonathan V. Sweedler9 Posttranslational Processing of Secretory Proteins 171Nabil G. Seidah and Johann Guillemot10 Neuropeptide Receptors 195Stephen J. Lolait, James A. Roper, Georgina G.J. Hazell, Yunfei Li, Fiona J. Thomson, and Anne-Marie O'CarrollPart C The Tool Kit11 Germline Transgenesis 219Jim Pickel12 Somatic Transgenesis (Viral Vectors) 243Valery Grinevich, H. Sophie Knobloch-Bollmann, Lena C. Roth, Ferdinand AlthammerAndrii Domanskyi, Ilya A. Vinnikov, Marina Eliava, Megan Stanifer, and Steeve Boulant13 Optogenetics Enables Selective Control of Cellular Electrical Activity 275Ryuichi Nakajima, Sachiko Tsuda, Jinsook Kim, and George J. Augustine14 Non-Mammalian Models for Neurohypophysial Peptides 301Einav Wircer, Shifra Ben-Dor, and Gil LevkowitzPart D Case Studies - Integration and Translation15 Osmoregulation 331David Murphy, Jose Antunes-Rodrigues, and Harold Gainer16 Food Intake, Circuitry, and Energy Metabolism 355Giles S.H. Yeo17 Stress Adaptation and the Hypothalamic-Pituitary-Adrenal Axis 375Greti Aguilera18 Neuroendocrine Control of Female Puberty: Genetic and Epigenetic Regulation 405Alejandro Lomniczi and Sergio R. Ojeda19 Oxytocin, Vasopressin, and Diversity in Social Behavior 423Lanikea B. King and Larry J. YoungGlossary 443Index 459