Inflammatory Bowel Diseases

Ashwin N. Ananthakrishnan MD, MPH, Assistant Professor of Medicine, Harvard Medical School; Director, Crohn's and Colitis Center, Massachusetts General Hospital, Boston, MA, USA.
 
Ramnik J. Xavier MD, Kurt Isselbacher Professor of Medicine, Harvard Medical School; Chief of Gastroenterology, Massachusetts General Hospital; Institute Member, Broad Institute of MIT and Harvard, Boston, MA, USA.
 
Daniel K. Podolsky MD, President, University of Texas Southwestern Medical Center; Professor of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA.

Inflammatory Bowel Diseases: A Clinician's Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterology trainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use. Written by the experts, Inflammatory Bowel Diseases: A Clinician's Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease.

Preface
 
Section I Pathogenesis and Clinical Features
 
1 Epidemiology and Pathogenesis
 
Clinical Take Home Messages
 
Epidemiology
 
Pathogenesis
 
Genetics
 
Microbiome
 
Environmental Triggers
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
2 Clinical Features and Diagnosis of Crohn's Disease
 
Clinical Take Home Messages
 
Clinical Features
 
Disease Course and Natural History
 
Diagnosis
 
History and Physical Examination
 
Laboratory Investigations
 
Serologic Markers
 
Endoscopy
 
Histology
 
Imaging Studies
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
3 Clinical Features and Diagnosis of Ulcerative Colitis
 
Clinical Take Home Messages
 
Clinical Features
 
Disease Course and Natural History
 
Diagnosis
 
History and Physical Examination
 
Laboratory Investigations
 
Serologic Markers
 
Endoscopy
 
Histology
 
Imaging Studies
 
Differential Diagnosis (UC and CD)
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
4 Extraintestinal Manifestations of Inflammatory Bowel Diseases
 
Clinical Take Home Messages
 
Arthritis and Arthropathy
 
Metabolic Bone Disease
 
Cutaneous Manifestations
 
Hepatobiliary Manifestations
 
Ophthalmologic Manifestations
 
Renal Complications
 
Thromboembolic and Cardiovascular Complications
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
Section II Therapeutic Agents
 
5 Aminosalicylates
 
Clinical Take Home Messages
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Safety
 
Multiple Choice Questions
 
References
 
Answers to Questions
 
6 Corticosteroids
 
Clinical Take Home Messages
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Safety
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
7 Immunomodulators
 
Clinical Take Home Messages
 
Thiopurines
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Safety
 
Methotrexate
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Safety
 
Calcineurin Inhibitors
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
8 Biologic Therapies
 
Clinical Take Home Messages
 
Infliximab
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Safety
 
Adalimumab
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Certolizumab Pegol
 
Efficacy in Crohn's Disease
 
Golimumab
 
Natalizumab
 
Vedolizumab
 
Newer Therapies
 
Case Studies and Multiple Choice Questions
 
References
 
Answers to Questions
 
9 Antibiotics
 
Clinical Take Home Messages
 
Efficacy in Ulcerative Colitis
 
Efficacy in Crohn's Disease
 
Other Microbial Modification Methods - Probiotics a

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