Beschreibung:
This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice. The book: Discusses where drugs and devices work, where they fail, and when they need to work with each other Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions Covers how a drug-device combination product is developed, tested, and regulated Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice.The book:* Discusses where drugs and devices work, where they fail, and when they need to work with each other* Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions* Covers how a drug-device combination product is developed, tested, and regulated* Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
FOREWORD viiPREFACE ixPART I BACKGROUNDS 11 Addressing Medical Device Challenges with Drug-Device Combinations 32 Historical Survey of Drug Delivery Devices 393 Development of Combination Product Drug Delivery Systems 664 Drug-Material Interactions, Materials Selection, and Manufacturing Methods 89PART II PRODUCTS 1175 Steroid-Releasing Lead 1196 Thromboresistant Vascular Graft 1427 Device-Enabled Drug Infusion Therapies 1828 Promus Element Plus®: A Drug-Eluting Stent 2149 Infuse® Bone Graft 241INDEX 261