Biosurfaces

Ideal as a graduate textbook, this title is aimed at helping design effective biomaterials, taking into account the complex interactions that occur at the interface when a synthetic material is inserted into a living system. Surface reactivity, biochemistry, substrates, cleaning, preparation, and coatings are presented, with numerous case studies and applications throughout. Highlights include: Starts with concepts and works up to real-life applications such as implantable devices, medical devices, prosthetics, and drug delivery technology Addresses surface reactivity, requirements for surface coating, cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processing strategies

Ideal as a graduate textbook, this title is aimed at helpingdesign effective biomaterials, taking into account the complexinteractions that occur at the interface when a synthetic materialis inserted into a living system. Surface reactivitybiochemistry, substrates, cleaning, preparation, and coatingsare presented, with numerous case studies and applicationsthroughout.Highlights include:* Starts with concepts and works up to real-life applicationssuch as implantable devices, medical devices, prosthetics, and drugdelivery technology* Addresses surface reactivity, requirements for surface coatingcleaning and preparation techniques, and characterization* Discusses the biological response to coatings* Addresses biomaterial-tissue interaction* Incorporates nanomechanical properties and processingstrategies

Chapter 1. Introduction to Biomaterials1.1 Introduction1.2 SummaryChapter 2. Tissue Interaction with Biomaterials2.1 Introduction2.2 Protein adsorption and Cell adhesion2.3 Cell Migration2.4 Controlled Cell Deposition2.5 Extracellular Matrix2.6 BiomineralizationChapter 3. Host Response of Implanted Biomaterials3.1 Immune Response to Implanted Biomaterials3.2 Transplant Immunology3.3 BiocomaptibilityChapter 4. Fundamentals of Surface Modification4.1 Introduction4.2 Surface Properties of Biomaterials4.3 Surface modifications4.4 ApplicationsChapter 5. Multi Length Scale Hierarchy in NaturalMaterials5.1 Introduction5.2 Multi Length-scale Hierarchy5.3 Human Bone5.4 Turtle shell5.5 Wood5.6 Silk5.7 Nacre5.8 Gecko-feet5.9 Lotus LeafChapter 6. Superhydrophobic Surfaces6.1 Introduction6.2 Surfaces and superhydrophobicity in nature6.3 Classification of surfaces6.4 Mechanics and nature of wetting6.5 Fabrication of artificial superhydrophobic surfaces6.6 Preparation of metallic superhydrophobic surfaces6.7 Controlled wettability surfaces (CWS)6.8 ConclusionsChapter 7. Surface Engineering and Modification for BiomedicalApplications7.1 Corrosion of Biomaterials and Need for Surface Coating forBiomedical Applications7.2 Surface Reactivity and Body Cell Response7.3 Key Requirements of Surface Coating7.4 Key Biomaterial Substrates7.5 Surface Preparation and Cleaning Techniques7.6 Surface Engineering and Coating Techniques7.7 Coatings for Biomedical Applications7.8. Biosurface CharacterizationChapter 8. Laser Engineering of Surface Structures8.1 Introduction8.2 Laser processing of biomaterials8.3 Laser-based prototyping methods8.4 Ultrafast laser pulses8.5 Neural implants8.6 Ophthalmic implants8.7 Laser fabrication of cardiovascular devices8.8 Laser-fabricated nanoscale materials8.9 Two photon polymerization8.10 Microneedle fabrication8.11 ConclusionsChapter 9. Processing and Nanomechanical Properties ofHydroxyapatite-Nanotube Biocomposite9.1 Introduction9.2 Processing of HA-Carbon Nanotube Composites9.3 Fracture Toughness and Tribological Properties of HA-CarbonNanotube Composites9.4 Adhesion of Bone Forming Cells on HA-CNT Surface9.5 Biomechanical Compatibility at Bone/Coated ImplantInterface9.6 HA-Boron Nitride Nano Tube (BNNT) Composites9.7 HA-TiO2 Nanotube Composites9.8 SummaryChapter 10. Applications of Biomaterials10.1 Multi-scale hierarchy in natural Bone10.2 Coronary Stents10.3 Medical Devices10.4 Drug DeliveryChapter 11. Nanosafety, Nanosocietal and NanoethicalIssues11.1 Governmental Environment and Health Safety OrganizationProtocols11.2 Related Safety Hazards11.3 Approach to Developing Safety Protocol for LaboratoryEnvironment11.4 Tendency of Nanoparticles11.5 Current Capability of Nanoparticle Filters