Drug Utilization Research

Monique Elseviers, Centre for Research and Innovation in Care, University of Antwerp, Belgium.

Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics.Drug Utilization Research is a unique, practical guide to the assessment and evaluation of prescribing practices and to interventions to improve the use of medicines in populations. Edited by an international expert team from the International Society for Pharmacoepidemiology (ISPE), DUR is the only title to cover both the methodology and applications of drug utilization research and covers areas such as health policy, specific populations, therapeutics and adherence.

List of contributorsList of reviewersAcknowledgementsAbout the companion websitePart 1 -INTRODUCTION1 INTRODUCTION TO DRUG UTILIZATION RESEARCHBjörn Wettermark, Monique Elseviers, Anna Birna Almarsdóttir, Morten Andersen, Ria Benko, Marion Bennie, Irene Eriksson, Brian Godman, Janet Krska, Elisabetta Poluzzi, Katja Taxis, Robert Vander Stichele, Vera Vlahoviæ-PalèevskiPart 2 -METHODOLOGY2 STUDY DESIGNS IN DRUG UTILIZATION RESEARCHBjörn Wettermark, Mirko Di Martino, Monique Elseviers3 PRIMARY DATA COLLECTION FOR DRUG UTILIZATION RESEARCHTatiana Chama Borges Luz, Evalill Nilsson4 SECONDARY DATA SOURCES FOR DRUG UTILIZATION RESEARCHIrene Eriksson, Luisa Ibanez5 CLASSIFICATION SYSTEMS FOR DRUGS AND DISEASESMarit Rønning, Stuart McTaggart6 MEASUREMENT UNITS OF DRUG UTILIZATIONHege Salvesen Blix7 INDIVIDUAL LEVEL DRUG UTILIZATION ANALYSESJesper Hallas, Henrik Støvring, Anton Pottegård8 MEASUREMENT OF DRUG EXPENDITURESabine Vogler, Jaana E. Martikainen9 BASIC STATISTICAL METHODS IN DRUG UTILIZATION RESEARCHDouglas T Steinke, Monique M Elseviers10 VISUALIZATION OF DRUG UTILIZATION DATAMaria Matuz, Ria Benko, Mikael Hoffmann11 MULTILEVEL ANALYSES IN DRUG UTILIZATION RESEARCHJuan Merlo12 DEFINING AND DEVELOPING QUALITY INDICATORS FOR DRUG UTILIZATIONStephen Campbell, Björn Wettermark, Morten Andersen13 QUALITATIVE METHODS IN DRUG UTILIZATION RESEARCHAnna Birna Almarsdóttir, Pia Bastholm RahmnerPart 3 - APPLIED DRUG UTILIZATION RESEARCHSection A - COMPARATIVE DRUG UTILIZATION RESEARCH14 COMPARISON OF DRUG UTILIZATION ACROSS DIFFERENT GEOGRAPHICAL AREASVera Vlahoviæ-Palèevski, Björn Wettermark, Luisa Ibanez, Robert Vander Stichele15 COMPARISON OF DRUG UTILIZATION IN DIFFERENT HEALTH CARE SETTINGSSean MacBride-Stewart, Ksenia Zagorodnikova, Irene Langner, Gisbert W Selke16 TIME-DEPENDENT AND SEASONAL VARIATION IN DRUG UTILIZATIONEric Van Ganse, Laurent Laforest , Niels Adriaenssens17 COMPARATIVE STUDIES ON PATIENT AND PRESCRIBER CHARACTERISTICSIrene Eriksson, Ulf Bergman, Vera Vlahoviæ-Palèevski, Mia von Euler18 COMPARATIVE STUDIES ON HEALTH SYSTEMSTatiana Chama Borges Luz, Claudia Osorio-de-Castro, Björn WettermarkSection B - DRUG UTILIZATION AND HEALTH POLICY19 INTRODUCTION TO DRUG UTILIZATION AND HEALTH POLICYBrian Godman, Hye-Young Kwon, Marion Bennie, Anna Birna Almarsdóttir20 MANAGED INTRODUCTION OF NEW DRUGSBrian Godman, Roberta Joppi, Marion Bennie, Saira Jan, Björn Wettermark21 MANAGEMENT OF DRUGS IN THE HEALTH CARE SYSTEMBrian Godman, Marion Bennie, Claudia Osorio-de-Castro, Vu Thi Thu Huong, Saira Jan22 PHARMACEUTICAL INDUSTRY AND HEALTH POLICYRichard Torbett, Donald Han, Indranil BagchiSecion B - DRUG UTILIZATION IN SPECIFIC POPULATIONS23 DRUG UTILIZATION IN PREGNANT WOMENHedvig Nordeng24 DRUG UTILIZATION IN THE PAEDIATRIC POPULATIONAntje Neubert, Katja Taxis, Ian Wong25 DRUG UTILIZATION IN OLDER PEOPLEKatja Taxis, David O'Sullivan, Shane Cullinan, Stephen ByrneSection C - DRUG UTILIZATION IN SPECIFIC THERAPEUTIC AREAS26 DRUG UTILIZATION RESEARCH IN THE AREA OF ANTIBIOTICSRia Benko, Marion Bennie, Samuel Coenen27 DRUG UTILIZATION RESEARCH IN THE AREA OF CARDIOVASCULAR MEDICINESElisabetta Poluzzi, Maarit Jaana Korhonen28 DRUG UTILIZATION RESEARCH IN THE AREA OF ANALGESICS AND PSYCHOTROPICSHelga Zoëga, Alesha Smith, Nadia Barozzi29 DRUG UTILIZATION RESEARCH IN THE AREA OF BIOLOGICALSCarlo Piccinni, Luigi Naldi , Martin Neovius30 DRUG UTILIZATION RESEARCH IN THE AREA OF CANCER DRUGSNils Wilking, Thomas Hofmarcher, Ulla Wilking, Bengt JönssonSection D - DETERMINANTS OF DRUG UTILIZATION31 HEALTH SYSTEM PERSPECTIVESPaul Spivey, Brian Godman32 PRESCRIBER PERSPECTIVESColin Bradley, Kathleen Holloway, Janet Krska33 PATIENT PERSPECTIVESJanine Traulsen, Nicky Britten, Janet KrskaSection E - ADHERENCE AND DRUG UTILIZATION RESEARCH34 AN INTRODUCTION TO ADHERENCE RESEARCHBernard Vrijens35 ASSESSMENT OF MEDICATION ADHERENCE IN FIELD RESEARCHMonique Elseviers, Bernard Vrijens36 ASSESSMENT OF ADHERENCE TO DRUG TREATMENT IN DATABASE RESEARCHJean-Pierre Grégoire, Jocelyne Moisan37 INTERVENTIONS TO IMPROVE ADHERENCE TO DRUG TREATMENTMarie Paule Schneider, Jennifer Celio, Yoleen van Camp, Matthias CavassiniSection F - THE ROLE OF DRUG UTILIZATION WITHIN THE FIELD OF PHARMACOEPIDEMIOLOGY38 DRUG UTILIZATION RESEARCH AND RISK MANAGEMENTGiampiero Mazzaglia, Peter Mol39 DRUG UTILIZATION RESEARCH AND METHODS OF PHARMACOVIGILANCEEmanuel Raschi, Fabrizio De Ponti40 DRUG UTILIZATION RESEARCH AND THE REGULATOR'S PERSPECTIVE IN PHARMACOVIGILANCEXavier Kurz, Kevin Blake41 DRUG UTILIZATION RESEARCH AND OUTCOME RESEARCHHenrik Toft Sørensen, Gianluca Trifirò42 DRUG UTILIZATION RESEARCH AND PHARMACOECONOMICSCara Usher, Kathleen Bennett, Lorenzo G Mantovani, Dyfrig HughesSection G - ASSESSMENT AND IMPROVEMENT OF THE QUALITY OF MEDICINE USE43 QUALITY INDICATORS FOR PRESCRIBING - WHAT DO WE MEASURE?Petra Denig, Flora Haaijer-Ruskamp, Lisa Pont44 QUALITY INDICATORS FOR PATIENT CARE IN PHARMACY PRACTICEHanne Herborg45 INTERVENTIONS WHICH INFLUENCE PRESCRIBING DECISIONS AND DRUG UTILIZATIONJens Søndergaard, Dorte Gilså Hansen, Debra Rowett46 DEVELOPMENT, DELIVERY AND EVALUATION OF IMPLEMENTATION PROGRAMSElizabeth Roughead, Andrew Gilbert47 TOWARDS BETTER UNDERSTANDING OF PRESCRIBING- ENHANCEMENT INTERVENTIONSFrank MayPart 4 -EPILOGUE48 THE MANY FUTURES OF DRUG UTILIZATION RESEARCHHubert GM Leufkens, Frank May, Nicky BrittenGlossaryIndex