Chemistry of Metalloproteins

Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Addresses the full gamut of questions in metalloproteinscienceFormatted as a question-and-answer guide, this book examines allmajor families of metal binding proteins, presenting our mostcurrent understanding of their structural, physicochemical, andfunctional properties. Moreover, it introduces new and emergingmedical applications of metalloproteins. Readers will discover boththe underlying chemistry and biology of this important area ofresearch in bioinorganic chemistry.Chemistry of Metalloproteins features a building blockapproach that enables readers to master the basics and then advanceto more sophisticated topics. The book begins with a generalintroduction to bioinorganic chemistry and metalloproteins. Nextit covers:* Alkali and alkaline earth cations* Metalloenzymes* Copper proteins* Iron proteins* Vitamin B12* ChlorophyllChapters are richly illustrated to help readers fully grasp allthe chemical concepts that govern the biological action ofmetalloproteins. In addition, each chapter ends with a list ofsuggested original research articles and reviews for furtherinvestigation of individual topics.Presenting our most current understanding of metalloproteinsChemistry of Metalloproteins is recommended for students andresearchers in coordination chemistry, biology, and medicine.Each volume of the Wiley Series in Protein and Peptide Scienceaddresses a specific facet of the field, reviewing the latestfindings and presenting a broad range of perspectives. The volumesin this series constitute essential reading for biochemistsbiophysicists, molecular biologists, geneticists, cell biologistsand physiologists as well as researchers in drug design anddevelopment, proteomics, and molecular medicine with an interest inproteins and peptides.

Preface ix1 Introduction 1Proteins: Formation, Structures, and Metalloproteins, 4References, 282 Alkali and Alkaline Earth Cations 31References, 673 Nonredox Metalloenzymes 71Carboxypeptidases, 75Carbonic Anhydrase, 84Alcohol Dehydrogenase, 88References, 914 Copper Proteins 95Introduction, 95Electronic Spectra of Copper Ions, 96ESR Spectra of Copper Ions, 105Copper Proteins, 117Plastocyanin, 119Azurin and Stellacyanin, 127Superoxide Dismutase, 131Hemocyanin, 135Ascorbic Oxidase, 139References, 1425 Iron Proteins 147Introduction, 147Electronic Spectra of Iron Ions, 148Mössbauer Spectroscopy of Iron Ions, 155ESR Spectra of Iron (III), 161Iron Bioavailability, 166Siderophores, 171Iron Storage and Transfer Proteins, 184Ferritin, 184Transferrin, 187Dioxygenase Iron Proteins, 195Iron-Sulfur Proteins, 207Rubredoxin, 207Ferredoxins, 2122Fe-2S Ferredoxins, 2124Fe-4S Ferredoxins, 221Aconitase, 226Hydroxylases, 229Hydrogenases, 232Nitrogenases, 240Binuclear Iron Proteins, 251Hemerythrin, 253Ribotide Reductase, Purple Acid Phosphate, and MethaneMonooxygenase, 260Hemoproteins: Classification and Behavior of Heme in Absence ofGlobins, 267Myoglobin and Hemoglobin, 275Myoglobin, 275Hemoglobin, 280Cytochrome C, 298Electron Transfer in Porphyrins and Metalloporphyrins, 301Catalases, 311Peroxidases, 315Cytochrome P-450, 322Electronic Spectra of Hemoproteins, 327ESR Spectra of Hemoproteins, 362References, 3786 Vitamin B12 393References, 4057 Chlorophyll 407References, 421Index 423